School of Psychology, University College Dublin, Newman Building, Belfield, Dublin 4, Ireland.
Child Psychiatry Hum Dev. 2021 Oct;52(5):841-855. doi: 10.1007/s10578-020-01071-9. Epub 2020 Sep 27.
Preterm birth is associated with an increased risk for autism spectrum disorder, with various factors proposed to underlie this relationship. The aim of this systematic review was to provide a narrative synthesis of the literature regarding the prenatal, perinatal and postnatal factors associated with autism spectrum disorder in children born preterm. Medline, Embase and PsycINFO databases were searched via Ovid to identify studies published from January 1990 to December 2019. Original studies in which a standardized diagnostic tool and/or clinical assessment was used to diagnose autism, along with a risk factor analysis to identify associated predictors, were included. A total of 11 eligible studies were identified. Male sex, being born small for gestational age and general cognitive impairment were the most robust findings, with each reported as a significant factor in at least two studies. Comparisons across studies were limited by variation in risk factor measurement and gestational age ranges investigated.
早产与自闭症谱系障碍的风险增加有关，有各种因素被提出是这种关系的基础。本系统综述的目的是对有关早产儿自闭症谱系障碍相关产前、围产期和产后因素的文献进行叙述性综合。通过 Ovid 在 Medline、Embase 和 PsycINFO 数据库中进行检索，以确定自 1990 年 1 月至 2019 年 12 月期间发表的研究。纳入了使用标准化诊断工具和/或临床评估来诊断自闭症的原始研究，以及进行风险因素分析以确定相关预测因素的研究。共确定了 11 项符合条件的研究。男性、出生时小于胎龄和一般认知障碍是最有力的发现，每个发现都至少有两项研究报道为显著因素。由于风险因素测量和研究中调查的胎龄范围的差异，研究之间的比较受到限制。
