极早产儿高存活率队列中自闭症谱系障碍的诊断率：一项横断面研究。

Diagnostic rate of autism spectrum disorder in a high-survival cohort of children born very preterm: A cross-sectional study.

机构信息

Department of Pediatrics, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan.

Center for Human Development and Family Science, Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

出版信息

Int J Dev Neurosci. 2022 Apr;82(2):188-195. doi: 10.1002/jdn.10168. Epub 2022 Jan 5.

DOI:10.1002/jdn.10168

PMID:34970792

Abstract

To investigate the diagnostic rate of autism spectrum disorder (ASD) in a high-survival cohort of very preterm children, 77 infants born very preterm (<32 weeks of gestation) were assessed at age 4-6 years old using the Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) and the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5). Sixteen children (20.8%) were classified as both DSM-5-positive ASD and ADOS-2-identified "autism," which were defined as confirmed ASD in this study. Our result suggests that the prevalence of ASD in very preterm children might be much higher than reported in previous studies when all children were individually evaluated. Further studies in a large sample are required to clarify the true risk of ASD in preterm birth.

摘要

为了调查在极早产儿高存活率队列中自闭症谱系障碍（ASD）的诊断率，对 77 名极早产儿（<32 孕周）婴儿在 4-6 岁时使用自闭症诊断观察量表，第二版（ADOS-2）和精神障碍诊断与统计手册，第五版（DSM-5）进行评估。16 名儿童（20.8%）被归类为DSM-5 阳性 ASD 和 ADOS-2 确定的“自闭症”，在本研究中被定义为确诊 ASD。我们的研究结果表明，当所有儿童都进行单独评估时，极早产儿中 ASD 的患病率可能比之前的研究报道高得多。需要进一步的大样本研究来明确早产儿出生中 ASD 的真实风险。