Department of Gynaecology and Obstetrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Translation Medicine Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Arch Gynecol Obstet. 2021 Feb;303(2):547-556. doi: 10.1007/s00404-020-05804-y. Epub 2020 Sep 26.
Inflammation has been reported as a facilitator in cervical oncogenesis, but the correlation between inflammation and cytological abnormality remains uncertain. The aim of this study was to investigate the correlation between inflammation and cytological abnormality.
ThinPrep cytological test (TCT) was used to detect cervical cytological abnormalities and inflammation degrees of 46,255 women in this prospective cross-sectional study. Histopathological examination was used to define the cervical intraepithelial neoplasia (CIN) in patients with cervical cytological abnormalities.
The study revealed that 8.87% (4102/46,255) of TCT results had cytological abnormalities. The 4102 included cases were classified as the case group, including atypical squamous cells (ASC), low-grade squamous intraepithelial lesions (LSIL) and high-grade squamous intraepithelial lesions (HSIL). Women with negative intraepithelial lesion or malignancy (NILM) were classified as the control group. About 88.83% (3644/4102) of women with cytological abnormalities showed inflammations. The rate of severe inflammation was significantly higher in the case group than the control group (23.86% vs. 2.0%, P = 0.000). Our results also showed that patients with severe inflammation had a significantly increasing incidence of cytological abnormality by 12.598 times and elevated the risk of HSIL by 756.47 times, compared to the inflammation negative group.
Severe inflammation was positively related to HSIL. Patients with severe cervical inflammation should be given more follow-ups and regular examinations and treated more carefully than those with mild or no inflammation.
炎症被报道为宫颈癌发生的促进因素，但炎症与细胞学异常之间的相关性仍不确定。本研究旨在探讨炎症与细胞学异常之间的相关性。
本前瞻性横断面研究采用 ThinPrep 细胞学检测（TCT）检测 46255 名女性的宫颈细胞学异常和炎症程度。对宫颈细胞学异常患者进行组织病理学检查以确定宫颈上皮内瘤变（CIN）。
研究显示，TCT 结果有 8.87%（4102/46255）出现细胞学异常。4102 例患者分为病例组，包括非典型鳞状细胞（ASC）、低级别鳞状上皮内病变（LSIL）和高级别鳞状上皮内病变（HSIL）。无上皮内瘤变或恶性肿瘤（NILM）的女性被分为对照组。约 88.83%（3644/4102）的细胞学异常患者有炎症。病例组严重炎症的发生率明显高于对照组（23.86% vs. 2.0%，P=0.000）。我们的结果还表明，与炎症阴性组相比，严重炎症患者的细胞学异常发生率显著增加 12.598 倍，HSIL 风险增加 756.47 倍。
严重炎症与 HSIL 呈正相关。患有严重宫颈炎症的患者应比轻度或无炎症的患者接受更多的随访和定期检查，并更仔细地治疗。
