依库珠单抗治疗 COVID-19 儿童患者肾衰竭。
Eculizumab treatment for renal failure in a pediatric patient with COVID-19.
机构信息
Division of Pediatric Nephrology, Columbia University Vagelos College of Physicians and Surgeons, 622 West 168th Street, PH 17-102B, New York, NY, 10032, USA.
Division of Pediatric Bone Marrow Transplantation, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA.
出版信息
J Nephrol. 2020 Dec;33(6):1373-1376. doi: 10.1007/s40620-020-00858-2. Epub 2020 Sep 26.
While there are increasing reports of acute kidney injury among hospitalized adults with COVID-19, there is still limited information on renal complications associated with COVID-19 in children. The cause of kidney involvement in COVID-19 is likely multifactorial, and appears to involve a complex process, including complement dysregulation and thrombotic microangiopathy. We present a pediatric case of COVID-19 and renal failure due to thombotic microangiopathy, successfully treated with eculizumab.
虽然越来越多的报告表明 COVID-19 住院成年患者中存在急性肾损伤，但关于 COVID-19 相关儿童肾脏并发症的信息仍然有限。COVID-19 导致肾脏受累的原因可能是多因素的，似乎涉及一个复杂的过程，包括补体失调和血栓性微血管病。我们报告了一例 COVID-19 患儿因血栓性微血管病导致肾衰竭的病例，该病例成功地接受了依库珠单抗治疗。
Zotero 插件