Srivastava Atul Kumar, Panda Sanjay
Classified Specialist (Medicine) & Nephrologist, Base Hospital Delhi Cantt, New Delhi, India.
Senior Advisor (Medicine) & Nephrologist, Base Hospital Delhi Cantt, New Delhi, India.
Med J Armed Forces India. 2024 Dec;80(Suppl 1):S297-S300. doi: 10.1016/j.mjafi.2023.09.008. Epub 2023 Oct 17.
The SARS-CoV-2 virus can cause thrombotic microangiopathy (TMA) by alternate pathway activation. We present a case of a young female patient who presented with fever and dialysis-dependent acute kidney injury. On evaluation, she was diagnosed with COVID-19-induced complement-mediated thrombotic microangiopathy (CM-TMA). She was initially managed with plasma exchange (PLEX). However, because of poor response to PLEX, she was administered Inj Eculizumab. She became dialysis independent and had normal renal function on follow-up visits.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒可通过替代途径激活引发血栓性微血管病（TMA）。我们报告一例年轻女性患者，她出现发热和依赖透析的急性肾损伤。经评估，她被诊断为新型冠状病毒肺炎（COVID-19）诱导的补体介导的血栓性微血管病（CM-TMA）。她最初接受血浆置换（PLEX）治疗。然而，由于对PLEX反应不佳，她接受了依库珠单抗注射治疗。她不再依赖透析，随访时肾功能正常。
