Page C P
Int J Tissue React. 1987;9(1):27-32.
Platelet activating factor (PAF) is able to induce a long-lasting non-specific increase in bronchial hyperreactivity in both experimental animals and man. In the guinea-pig, PAF-induced bronchial hyperreactivity is secondary to platelet activation and associated with a recruitment of platelets into the lung. As platelets have been shown to be activated in clinical asthma and platelet abnormalities are a feature of this disease, it would seem justified to evaluate further the role of PAF and platelets in the induction of the bronchial hyperreactivity which characterizes asthma.
血小板活化因子（PAF）能够在实验动物和人类中诱导支气管高反应性出现长期的非特异性增加。在豚鼠中，PAF诱导的支气管高反应性继发于血小板活化，并与血小板向肺内募集有关。由于血小板在临床哮喘中已被证明处于活化状态，且血小板异常是该疾病的一个特征，因此进一步评估PAF和血小板在诱发哮喘所特有的支气管高反应性中的作用似乎是合理的。
