Mencia-Huerta J M, Touvay C, Pfister A, Braquet P
Laboratoire d'anatomopathologie, Université Paris.
Allerg Immunol (Paris). 1988 Dec;22 Suppl 10:21, 23-4.
The possible role of PAF in the development of bronchial hyperreactivity was investigated using Alzet osmotic minipumps loaded with PAF or solvent alone and implanted in male Hartley guinea-pigs. Compared to animals treated with solvent alone, those receiving PAF (20 micrograms/kg/h for 15 days) exhibited a hyperreactivity to histamine. The lungs from PAF-treated were congestive in appearance, bronchi and the bronchioli were contracted, Reisseissen muscles were markedly hypertrophied and a muciparous metaplasia of the epithelium was observed. In addition, the number of eosinophils was significantly increased in the parenchyma, as was the number of mast cells in the peribronchial regions. These data indicate that long term-treatment with PAF induces profound alterations in the respiratory system resembling those observed in asthmatic patients. They also strengthen the also strengthen the role of PAF in the development of bronchial hyperreactivity.
使用装有PAF或仅装有溶剂的Alzet渗透微型泵并将其植入雄性Hartley豚鼠体内，研究了PAF在支气管高反应性发展中的可能作用。与仅用溶剂处理的动物相比，接受PAF（20微克/千克/小时，持续15天）的动物对组胺表现出高反应性。接受PAF处理的动物的肺外观充血，支气管和细支气管收缩，平滑肌明显肥大，观察到上皮细胞有黏液化生。此外，实质内嗜酸性粒细胞数量显著增加，支气管周围区域肥大细胞数量也增加。这些数据表明，长期用PAF治疗会引起呼吸系统的深刻改变，类似于在哮喘患者中观察到的改变。它们还强化了PAF在支气管高反应性发展中的作用。
