Department of Dermatology, Hadassah Medical Center, Hebrew University of Jerusalem, The Faculty of Medicine, Jerusalem, Israel.
Department of Dermatology, University of Münster, Münster, Germany.
Trends Mol Med. 2021 Jan;27(1):60-74. doi: 10.1016/j.molmed.2020.09.002. Epub 2020 Sep 24.
Human skin responds to numerous neurohormones, neuropeptides, and neurotransmitters that reach it via the vasculature or skin nerves, and/or are generated intracutaneously, thus acting in a para- and autocrine manner. This review focuses on how neurohormones impact on human skin physiology and pathology. We highlight basic concepts, major open questions, and translational research perspectives in cutaneous neuroendocrinology and argue that greater emphasis on neuroendocrine human skin research will foster the development of novel dermatological therapies. Furthermore, human skin and its appendages can be used as highly accessible and clinically relevant model systems for probing nonclassical, ancestral neurohormone functions. This calls for close interdisciplinary collaboration between dermatologists, skin biologists, neuroendocrinologists, and neuropharmacologists.
人体皮肤对通过血管或皮肤神经到达皮肤的多种神经激素、神经肽和神经递质，以及在皮肤内产生的神经激素、神经肽和神经递质，作出反应，从而以旁分泌和自分泌的方式发挥作用。这篇综述重点介绍了神经激素如何影响人体皮肤的生理学和病理学。我们强调了皮肤神经内分泌学中的基本概念、主要开放性问题和转化研究观点，并认为更加重视神经内分泌的人体皮肤研究将促进新型皮肤病治疗方法的发展。此外，人体皮肤及其附属物可以用作高度可及和临床相关的模型系统，以研究非经典的、原始的神经激素功能。这需要皮肤科医生、皮肤生物学家、神经内分泌学家和神经药理学家之间密切的跨学科合作。
