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外周皮肤冷却对超重期间神经内分泌、白细胞及血液学反应的影响

Impact of peripheral skin cooling on neuroendocrine leukocytic and hematological reactions during Hypergravity.

作者信息

Nordine Michael, Kagelmann Niklas, Kloka Jan, Gunga Hanns-Christian, Heinz Viktor, Pilz Niklas, Opatz Oliver, Bothe Tomas L

机构信息

Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Goethe University Frankfurt, University Hospital Frankfurt, Theodor-Stern Kai 7, 60590, Frankfurt, Germany.

Institute of Physiology, Center for Space Medicine and Extreme Environments Berlin, Charité -Universitätsmedizin Berlin, Berlin, Germany.

出版信息

NPJ Microgravity. 2025 Jul 2;11(1):30. doi: 10.1038/s41526-025-00486-9.

DOI:10.1038/s41526-025-00486-9
PMID:40603301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12223314/
Abstract

Optimal neuroendocrine responses are essential during hypergravity (+Gz) exposure. Peripheral skin cooling (PSC) may enhance neuroendocrine function, potentially improving +Gz resiliency and influencing leukocyte and hematologic factors. This study investigated whether PSC augments the cumulative +Gz stress index (CGSI) and shifts it toward noradrenergic dependency. Eighteen men underwent a graded +Gz profile in a crossover design, with PSC applied using Arctic Sun cooling pads. Neuroendocrine and blood profiles were assessed pre- and post-+Gz. CGSI did not differ between groups, but serum osmolality increased only in PSC (p = 0.03). In PSC, CGSI correlated with norepinephrine (p < 0.01, r = 0.71) and other markers, suggesting enhanced norepinephrine responsiveness despite similar serum levels. This response may be cardio-protective for space missions and ICU patients. Additionally, baseline serum metanephrine emerged as a potential marker for +Gz resilience, with PSC showing potential leukocytic and hematologic involvement in CGSI.

摘要

在高重力（+Gz）暴露期间，最佳神经内分泌反应至关重要。外周皮肤冷却（PSC）可能会增强神经内分泌功能，从而有可能提高对+Gz的耐受性并影响白细胞和血液学因素。本研究调查了PSC是否会增加累积+Gz应激指数（CGSI）并使其向去甲肾上腺素依赖性转变。18名男性采用交叉设计进行了分级+Gz实验，使用北极太阳冷却垫进行PSC。在+Gz前后评估神经内分泌和血液指标。两组之间的CGSI没有差异，但仅在PSC组中血清渗透压升高（p = 0.03）。在PSC组中，CGSI与去甲肾上腺素相关（p < 0.01，r = 0.71）以及其他标志物相关，这表明尽管血清水平相似，但去甲肾上腺素反应性增强。这种反应可能对太空任务和重症监护病房患者具有心脏保护作用。此外，基线血清间甲肾上腺素成为+Gz耐受性的潜在标志物，PSC显示在CGSI中可能存在白细胞和血液学方面的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c06/12223314/a25ad9f1f24b/41526_2025_486_Fig9_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c06/12223314/34f8490f3800/41526_2025_486_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c06/12223314/a25ad9f1f24b/41526_2025_486_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c06/12223314/2addcf410bd4/41526_2025_486_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c06/12223314/95d030ffbcc4/41526_2025_486_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c06/12223314/010c0990fe31/41526_2025_486_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c06/12223314/f81c610eea89/41526_2025_486_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c06/12223314/08ab80812433/41526_2025_486_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c06/12223314/676d33fabe8c/41526_2025_486_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c06/12223314/153251132c37/41526_2025_486_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c06/12223314/34f8490f3800/41526_2025_486_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c06/12223314/a25ad9f1f24b/41526_2025_486_Fig9_HTML.jpg

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