Young R S, Alger P M, Bauer L, Lauderbaugh D
J Child Neurol. 1986 Oct;1(4):361-3. doi: 10.1177/088307388600100408.
Some pediatric neurologists maintain that mephobarbital (Mebaral) causes fewer behavioral side effects than phenobarbital. Because this hypothesis has not been previously tested, we conducted a prospective, double-blind, randomized, crossover study of these two anticonvulsants. Both drugs were equally effective in reducing the frequency of seizure, although serum phenobarbital levels were significantly higher when the patients were taking phenobarbital compared to mephobarbital. As measured by the Abbott Parent Questionnaire, there was no significant deterioration of behavior with either phenobarbital or mephobarbital, regardless of which drug was administered first.
一些儿科神经学家认为，美索比妥（米那）引起的行为副作用比苯巴比妥少。由于这一假设此前尚未得到验证，我们对这两种抗惊厥药物进行了一项前瞻性、双盲、随机、交叉研究。两种药物在降低癫痫发作频率方面同样有效，不过与服用美索比妥时相比，患者服用苯巴比妥时血清苯巴比妥水平显著更高。根据雅培家长问卷的测量结果，无论先服用哪种药物，服用苯巴比妥或美索比妥后行为均无明显恶化。
