Wu Biwen, Cai Jiaye, Yao Ying, Pan Yu, Pan Liuqing, Zhang Lisan, Sun Yi
Electroencephalogram Unit, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
Center for Sleep Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 Aug 25;49(4):455-461. doi: 10.3785/j.issn.1008-9292.2020.08.02.
To investigate the effect of obstructive sleep apnea (OSA) on different sleep stages, and the relationship between N3 stage of non-rapid eye movement sleep and respiratory abnormal events.
A total of 188 adult patients who underwent overnight polysomnography(PSG)monitoring in Sir Run Run shaw Hospital of Zhejiang University from June 24th to December 26th 2019 were enrolled in the study. OSA patients were classified into 3 groups (mild, moderate and severe) according to the apnea-hypopnea index (AHI). PSG data, AHI and the lowest SPO in each stage of sleep were compared among three groups.
There was no significant difference in total sleep time and sleep efficiency among patients with different severity of OSA (all >0.05). The proportion of N3 stage in moderate and severe OSA groups were significantly smaller than that in mild OSA group (all <0.05). The proportion of N3 stage in severe OSA group was also smaller than that in moderate OSA group (<0.05). In addition, severe OSA group had a longer latency of N3 stage than mild and moderate OSA groups (all <0.05). The latency of N3 stage in moderate OSA group was longer than that in mild OSA group (<0.05). The AHI in N3 stage was markedly lower than that in other sleep stages (all <0.01), regardless of the severity of OSA. Supine AHI in N3 stage in mild and moderate groups was significantly lower than that in N1, N2 and rapid eye movement (REM) stages (all <0.01). Supine AHI in N3 stage in severe group was also lower than that in N2 and REM stages (<0.05 or <0.01). The lowest SPO in N3 stage was significantly higher than that in N1, N2 and REM stages (<0.05 or <0.01), regardless of the severity of OSA.
s The proportion of N3 stage is lower in OSA patients, and N3 stage has less sleep respiratory events than non-N3 stages. The results suggest that the increased N3 stage proportion may indicate less severity of OSA.
探讨阻塞性睡眠呼吸暂停（OSA）对不同睡眠阶段的影响，以及非快速眼动睡眠N3期与呼吸异常事件之间的关系。
选取2019年6月24日至12月26日在浙江大学医学院附属邵逸夫医院接受整夜多导睡眠图（PSG）监测的188例成年患者纳入研究。根据呼吸暂停低通气指数（AHI）将OSA患者分为3组（轻度、中度和重度）。比较三组患者的PSG数据、AHI及各睡眠阶段的最低血氧饱和度（SPO）。
不同严重程度的OSA患者总睡眠时间和睡眠效率差异无统计学意义（均>0.05）。中度和重度OSA组的N3期比例显著低于轻度OSA组（均<0.05）。重度OSA组的N3期比例也低于中度OSA组（<0.05）。此外，重度OSA组N3期的潜伏期长于轻度和中度OSA组（均<0.05）。中度OSA组N3期的潜伏期长于轻度OSA组（<0.05）。无论OSA严重程度如何，N3期的AHI均显著低于其他睡眠阶段（均<0.01）。轻度和中度组N3期的仰卧位AHI显著低于N1、N2和快速眼动（REM）期（均<0.01）。重度组N3期的仰卧位AHI也低于N2和REM期（<0.05或<0.01）。无论OSA严重程度如何，N3期的最低SPO均显著高于N1、N2和REM期（<0.05或<0.01）。
OSA患者的N3期比例较低，且N3期的睡眠呼吸事件少于非N3期。结果表明，N3期比例增加可能提示OSA严重程度较低。
