Institute of Pharmaceutics, School of Pharmacy, Lanzhou University, Lanzhou, P.R. China.
Nat Prod Res. 2021 Dec;35(24):6083-6087. doi: 10.1080/14786419.2020.1824223. Epub 2020 Sep 28.
This work aimed to investigate the hepatoprotective effect of total flavonoids from The main compounds in licorice total flavonoids (LTF) were isolated from and their total content in LTF were more than 60%. Hepatoprotective effects of LTF were investigated in three kinds of hepatic injury mice model induced by high-fat emulsion, Chinese liquor and tetrachloromethane. Serum ALT, AST and ALP levels and hepatic MDA, TG, cholesterol, and hydroxyproline of hepatic injury mice were reduced by LTF. Simultaneously, hepatic SOD and glutathione were increased by LTF. These results suggested that LTF can repair liver tissue and reduce hepatic injury via alleviating inflammation, improving antioxidant enzyme activity and reducing oxidative stress in liver tissue and it may be a valuable natural source of hepatoprotective activity.
本研究旨在探讨甘草总黄酮的保肝作用。甘草总黄酮的主要化合物从甘草中分离得到，其总含量超过 60%。采用高脂乳剂、白酒和四氯化碳三种肝损伤小鼠模型研究甘草总黄酮的保肝作用。甘草总黄酮可降低肝损伤小鼠血清 ALT、AST 和 ALP 水平及肝 MDA、TG、胆固醇和羟脯氨酸含量，同时提高肝 SOD 和谷胱甘肽含量。这些结果表明，甘草总黄酮通过减轻炎症、提高抗氧化酶活性和降低肝组织氧化应激来修复肝组织，减轻肝损伤，可能是一种有价值的天然保肝活性物质来源。
