Centro Integrativo de Biología y Química Aplicada (CIBQA), Universidad Bernardo O'Higgins, General Gana 1702, Santiago, Chile.
Org Biomol Chem. 2020 Oct 14;18(39):7868-7875. doi: 10.1039/d0ob01620a.
Propylene carbonate is becoming a suitable green alternative to volatile organic solvents in the study of chemical reactions. In this study, an efficient method for nucleophilic degradation of five organophosphorus pesticides, fenitrothion, malathion, diazinon, parathion, and paraoxon, using propylene carbonate as a solvent is proposed. The effect of changing the nature of the nucleophile and the influence of microwave (MW) heating were investigated. A screening of temperatures (50 °C-120 °C) was performed under microwave heating. The pesticide degradation was followed by 31P NMR, and the extent of conversion (%) was calculated by the integration of phosphorus signals. Keeping in mind that recently it has been reported that some ionic liquids play a nucleophilic role, in this work we report for the first time the degradation of organophosphorus pesticides by using an amino acid-based ionic liquid such as Bmim[Ala] as a nucleophile and a bio-based solvent (propylene carbonate) as a reaction medium in combination with microwave heating.
碳酸丙烯酯在化学反应研究中正在成为一种替代挥发性有机溶剂的合适绿色替代品。在这项研究中，提出了一种使用碳酸丙烯酯作为溶剂的有效方法，用于亲核降解五种有机磷农药，如：fenitrothion、malathion、diazinon、parathion 和 paraoxon。研究了亲核试剂性质的变化以及微波（MW）加热的影响。在微波加热下进行了温度（50°C-120°C）的筛选。通过 31P NMR 跟踪农药的降解情况，并通过磷信号的积分计算转化率（%）。考虑到最近有报道称一些离子液体具有亲核作用，在这项工作中，我们首次报道了使用基于氨基酸的离子液体（如 Bmim[Ala]）作为亲核试剂和生物基溶剂（碳酸丙烯酯）作为反应介质，并结合微波加热，用于降解有机磷农药。
