Pavez Paulina, Figueroa Roberto, Medina Mayte, Millán Daniela, Falcone R Darío, Tapia Ricardo A
Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Casilla 306, Santiago 6094411, Chile.
Centro Integrativo de Biología y Química Aplicada (CIBQA), Universidad Bernardo O'Higgins, Santiago 6094411, Chile.
ACS Omega. 2020 Oct 5;5(41):26562-26572. doi: 10.1021/acsomega.0c03305. eCollection 2020 Oct 20.
A series of ionic liquids (ILs) composed by choline (Ch) as a cation and different amino acids (AA) as anions and their respective aqueous mixtures were prepared using different [Ch][AA] contents in a range of 0.4-46 mol % IL. These solvents were used for the first time to achieve an eco-friendlier Paraoxon degradation. The results show that [Ch][AA]/water mixtures are an effective reaction medium to degrade Paraoxon, even when the IL content in the mixture is low (0.4 mol % IL) and without the need of an extra nucleophile. Both the kinetics and the degradation pathways of pesticides depend on the nature of the AA on [Ch][AA] and the amount of an IL present in the mixture. We have demonstrated that in those mixtures with a low amount of [Ch][AA], the hydrolysis reaction is the main pathway for Paraoxon degradation, showing a catalytic effect of the IL. However, as the percentage of [Ch][AA] increases in the mixture, the nucleophilic attack of [Ch][AA] is evident. Finally, the aim of this study was to provide evidence of a promising and biocompatible methodology to degrade a toxic compound (Paraoxon) using a minimal quantity of an IL designed totally from natural resources.
制备了一系列以胆碱（Ch）为阳离子、不同氨基酸（AA）为阴离子的离子液体（ILs）及其各自的水混合体系，其中[Ch][AA]的含量在0.4 - 46 mol% IL范围内。这些溶剂首次被用于实现更环保的对氧磷降解。结果表明，即使混合物中离子液体含量较低（0.4 mol% IL）且无需额外亲核试剂，[Ch][AA]/水混合体系也是降解对氧磷的有效反应介质。农药的动力学和降解途径均取决于[Ch][AA]中氨基酸的性质以及混合物中离子液体的含量。我们已经证明，在那些[Ch][AA]含量较低的混合物中，水解反应是对氧磷降解的主要途径，显示出离子液体的催化作用。然而，随着混合物中[Ch][AA]百分比的增加，[Ch][AA]的亲核攻击变得明显。最后，本研究的目的是提供证据，证明一种有前景且生物相容的方法，即使用极少量完全由自然资源设计的离子液体来降解有毒化合物（对氧磷）。
