Program in Molecular Medicine, Hospital for Sick Children, Toronto, Canada.
Department of Biochemistry, University of Toronto, Toronto, Canada.
Biochem Soc Trans. 2020 Oct 30;48(5):2151-2158. doi: 10.1042/BST20200355.
What do we know about the molecular evolution of functional protein condensation? The capacity of proteins to form biomolecular condensates (compact, protein-rich states, not bound by membranes, but still separated from the rest of the contents of the cell) appears in many cases to be bestowed by weak, transient interactions within one or between proteins. Natural selection is expected to remove or fix amino acid changes, insertions or deletions that preserve and change this condensation capacity when doing so is beneficial to the cell. A few recent studies have begun to explore this frontier of phylogenetics at the intersection of biophysics and cell biology.
关于功能性蛋白质凝聚的分子进化，我们了解多少？在许多情况下，蛋白质形成生物分子凝聚物（无膜结合的紧凑、富含蛋白质的状态，但仍与细胞其余内容物分离）的能力似乎是由一种或多种蛋白质内的弱、短暂相互作用赋予的。当这种情况对细胞有益时，自然选择预计会去除或固定那些能保持和改变这种凝聚能力的氨基酸变化、插入或缺失。最近的一些研究已经开始在生物物理学和细胞生物学的交叉点探索这一系统发生学的前沿。
