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术前血流动力学预处理是否能改善老年创伤性髋部骨折患者的发病率和死亡率?一项回顾性队列研究。

Does preoperative hemodynamic preconditioning improve morbidity and mortality after traumatic hip fracture in geriatric patients? A retrospective cohort study.

机构信息

Klinik für Orthopädie Und Unfallchirurgie, Luzerner Kantonsspital, Spitalstrasse, 6000, Lucerne, Switzerland.

Department of Surgery, Diakonessenhuis, Utrecht, The Netherlands.

出版信息

Arch Orthop Trauma Surg. 2021 Sep;141(9):1491-1497. doi: 10.1007/s00402-020-03601-5. Epub 2020 Sep 25.

Abstract

INTRODUCTION

Dehydration is a major problem in the older population with traumatic hip fractures (THF). A preoperative hemodynamic preconditioning (PHP) protocol may help in achieving hemodynamic stability to ensure adequate perfusion and oxygenation using only clinical parameters to assess cardiovascular performance.

MATERIALS AND METHODS

A single-centre retrospective study in geriatric trauma patients was conducted in a Level 1 Trauma Centre in Switzerland. Patients over the age of 70 with THFs and with Portsmouth Physiological and Operative Severity Score for the enUmeration of Mortality (P-POSSUM) scores ≥ 5% who underwent surgical treatment between February 2015 and October 2017 were included. It was hypothesized that patients whose hemodynamic stability was optimised before surgery would have fewer complications and reduced mortality postoperatively. Primary outcomes were complications and mortality. Secondary outcomes were hospital length of stay (HLOS) and place of discharge.

RESULTS

100 patients were included in the PHP group and 79 patients were included in the non-PHP group. The median age was 86.5 (82-90) in the PHP group and 86 (82-90) in the non-PHP group. Patients who had been treated according to the PHP protocol showed a significant reduction in mortality at 30 days (p = 0.02). The PHP group showed an 8.1 and 3.5% reduced mortality at 90 days and at 1 year, respectively. The PHP group showed an 11.7% reduction of patients with complicated courses. No significant differences were seen in HLOS and discharge disposition.

CONCLUSIONS

The PHP group showed a significant reduction in short-term mortality, a reduction in long-term mortality, and a reduction in the number of patients with complicated courses. The PHP protocol is a safe, strictly regulated, non-invasive fluid resuscitation protocol for the optimization of geriatric patients with a THF that requires minimal effort.

LEVEL OF EVIDENCE

Level III, therapeutic.

摘要

引言

脱水是创伤性髋部骨折(THF)老年患者的主要问题。术前血流动力学预处理(PHP)方案可能有助于通过仅使用临床参数评估心血管功能来实现血流动力学稳定,以确保充足的灌注和氧合。

材料和方法

在瑞士的一家 1 级创伤中心进行了一项老年创伤患者的单中心回顾性研究。纳入 2015 年 2 月至 2017 年 10 月期间接受手术治疗且年龄超过 70 岁、THF 伴 Portsmouth 生理和操作严重程度评分用于死亡率估算(P-POSSUM)评分≥5%的患者。假设在手术前优化血流动力学稳定性的患者术后并发症和死亡率会更低。主要结局是并发症和死亡率。次要结局是住院时间(HLOS)和出院地点。

结果

PHP 组纳入 100 例患者,非 PHP 组纳入 79 例患者。PHP 组的中位年龄为 86.5(82-90)岁,非 PHP 组为 86(82-90)岁。根据 PHP 方案治疗的患者在 30 天时死亡率显著降低(p=0.02)。PHP 组在 90 天和 1 年时的死亡率分别降低了 8.1%和 3.5%。PHP 组有并发症的患者减少了 11.7%。HLOS 和出院去向无显著差异。

结论

PHP 组的短期死亡率显著降低,长期死亡率降低,并发症患者减少。PHP 方案是一种安全、严格规范、非侵入性的液体复苏方案,用于优化需要最小努力的 THF 老年患者。

证据水平

III 级,治疗。

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