Paskert J P, Yaremchuk M J, Randolph M A, Weiland A J
J Reconstr Microsurg. 1987 Apr;3(3):253-63. doi: 10.1055/s-2007-1006992.
Vascularized bone allografts (VBAs) could be useful adjuncts to the clinical reconstructive surgeon's arsenal. These grafts are known experimentally to be subject to host rejection. One way to control the rejection problem would be to develop specific immune unresponsiveness via host conditioning. Using a proven reliable model in inbred rats for studying heterotopic VBA transplantation, recipient animals were conditioned preoperatively with third-party unrelated blood, donor-specific blood (DSB) alone and with cyclosporine, and ultraviolet irradiated donor-specific blood. The combination of DSB plus cyclosporine delayed rejection of grafts across a strong histocompatibility barrier for three to four weeks. However, rejection was delayed across a weak histocompatibility barrier for five to six weeks using this same host pretreatment. The implications are that specific immunosuppression, although possible, is difficult to achieve in VBA transplantation, and that such techniques will rely on tissue-matching to minimize the genetic disparity between graft and host.
带血管蒂同种异体骨移植（VBA）可能是临床重建外科医生可用的有用辅助手段。实验表明，这些移植物会受到宿主排斥。控制排斥问题的一种方法是通过宿主预处理来产生特异性免疫无反应性。利用近交系大鼠中已证实可靠的模型来研究异位VBA移植，术前用第三方无关血液、单独的供体特异性血液（DSB）以及环孢素和紫外线照射的供体特异性血液对受体动物进行预处理。DSB加环孢素的组合使移植物跨越强组织相容性屏障的排斥反应延迟了三到四周。然而，使用相同的宿主预处理，移植物跨越弱组织相容性屏障的排斥反应延迟了五到六周。这意味着，虽然特异性免疫抑制在VBA移植中是可能的，但很难实现，并且此类技术将依赖于组织匹配以最小化移植物与宿主之间的遗传差异。
