Yaremchuk M J, Nettelblad H, Randolph M A, Weiland A J
Plast Reconstr Surg. 1985 Mar;75(3):355-62. doi: 10.1097/00006534-198503000-00009.
A heterotopic subcutaneous model for experimental vascularized bone allograft transplantation has been presented. This model uses genetically defined rats and allows serial assessment of graft viability. The reliability of this model has been proven by successful isograft transplantation. This model was used to study the effect of matching at the major histocompatibility complex on vascularized bone allograft survival. Whereas grafts transplanted across a minor histocompatibility barrier survived until sacrifice, grafts transplanted across a major histocompatibility barrier were victims of an acute rejection process. This study, therefore, showed genetic disparity to be a critical determinant of vascularized bone allograft survival. It indicates that primary vascularized bone allografts are as susceptible to rejection as heart and kidney allografts. For these reasons, it can be anticipated that genetic matching will be important in clinical vascularized bone allograft transplantation. The model used in this study should be useful for obtaining further fundamental immunologic information concerning vascularized bone allograft transplantation.
已提出一种用于实验性带血管骨同种异体移植的异位皮下模型。该模型使用基因明确的大鼠，并允许对移植物活力进行系列评估。该模型的可靠性已通过成功的同基因移植得到证实。此模型用于研究主要组织相容性复合体匹配对带血管骨同种异体移植存活的影响。尽管跨越次要组织相容性屏障移植的移植物存活至处死，但跨越主要组织相容性屏障移植的移植物则遭受急性排斥反应。因此，本研究表明基因差异是带血管骨同种异体移植存活的关键决定因素。这表明原发性带血管骨同种异体移植与心脏和肾脏同种异体移植一样易发生排斥反应。基于这些原因，可以预期基因匹配在临床带血管骨同种异体移植中很重要。本研究中使用的模型应有助于获取有关带血管骨同种异体移植的更多基础免疫学信息。
