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一种用于无导线心脏起搏器的微型心内膜电磁能量采集器。

A miniaturized endocardial electromagnetic energy harvester for leadless cardiac pacemakers.

机构信息

Department of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.

Sitem Center for Translational Medicine and Biomedical Entrepreneurship, University of Bern, Bern, Switzerland.

出版信息

PLoS One. 2020 Sep 28;15(9):e0239667. doi: 10.1371/journal.pone.0239667. eCollection 2020.

Abstract

Life expectancy of contemporary cardiac pacemakers is limited due to the use of an internal primary battery. Repeated device replacement interventions are necessary, which leads to an elevated risk for patients and an increase of health care costs. The aim of our study is to investigate the feasibility of powering an endocardial pacemaker by converting a minimal amount of the heart's kinetic energy into electric energy. The intrinsic cardiac muscle activity makes it an ideal candidate as continuous source of energy for endocardial pacemakers. For this reason, we developed a prototype able to generate enough power to supply a pacing circuit at different heart rates. The prototype consists of a mass imbalance that drives an electromagnetic generator while oscillating. We developed a mathematical model to estimate the amount of energy harvested from the right ventricle. Finally, the implemented prototype was successfully tested during in-vitro and in-vivo experiments.

摘要

由于使用内部原电池,当代心脏起搏器的预期寿命有限。需要反复进行设备更换干预,这会增加患者的风险和医疗保健成本。我们的研究目的是研究通过将心脏的少量动能转换为电能来为心内膜起搏器供电的可行性。内在的心肌活动使其成为心内膜起搏器的连续能源的理想选择。出于这个原因,我们开发了一个原型,能够产生足够的功率来为不同心率的起搏电路供电。该原型由一个质量不平衡的物体驱动,在振荡时驱动电磁发电机。我们开发了一个数学模型来估计从右心室收获的能量量。最后,实施的原型在体外和体内实验中都成功进行了测试。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db81/7521684/d946330f5dc8/pone.0239667.g001.jpg

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