MRC North West Hub for Trials Methodology Research, Department of Health Data Science, University of Liverpool, Block F Waterhouse Building, 1-5 Brownlow Street, Liverpool L69 3GL, United Kingdom.
Centre for Public Health, Institute of Clinical Sciences, Block B, Queen's University Belfast, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, United Kingdom.
J Clin Epidemiol. 2021 Jan;129:114-123. doi: 10.1016/j.jclinepi.2020.09.029. Epub 2020 Sep 26.
The aim of our review was to bring together studies that had assessed the uptake of core outcome sets (COS) to explore the level of uptake across different COS and areas of health.
We examined the citations of 337 COS reports to identify studies that had assessed the uptake of a particular COS in randomized controlled trials (RCTs) or systematic reviews (SRs).
We identified 24 studies that had assessed uptake in RCTs and two studies that had assessed uptake in SRs. The studies covered a total of 17/337 (5%) COS. Uptake rates reported for RCTs varied from 0% of RCTs (gout) to 82% RCTs (rheumatoid arthritis) measuring the full COS. Studies that assessed uptake of individual core outcomes showed a wide variation in uptake between the outcomes. Suggested barriers to uptake included lack of validated measures, lack of patient and other key stakeholder involvement in COS development, and lack of awareness of the COS.
Few studies have been undertaken to assess the uptake of COS in RCTs and SRs. Further studies are needed to assess whether COS have been implemented across a wider range of disease categories and to explore the barriers and facilitators to COS uptake.
本综述的目的是汇集评估核心结局集（COS）采用情况的研究，以探索不同 COS 和卫生领域的采用程度。
我们检查了 337 个 COS 报告的引用，以确定评估特定 COS 在随机对照试验（RCT）或系统评价（SR）中采用情况的研究。
我们确定了 24 项评估 RCT 中采用情况的研究和 2 项评估 SR 中采用情况的研究。这些研究总共涵盖了 17/337（5%）个 COS。报告的 RCT 采用率从 0%（痛风）到测量完整 COS 的 82%（类风湿关节炎）的 RCT 不等。评估个别核心结局采用情况的研究表明，不同结局之间的采用情况存在很大差异。采用的障碍包括缺乏经过验证的测量方法、缺乏患者和其他关键利益相关者对 COS 制定的参与，以及对 COS 的认识不足。
很少有研究评估 RCT 和 SR 中 COS 的采用情况。需要进一步研究，以评估 COS 是否已在更广泛的疾病类别中得到实施，并探讨采用 COS 的障碍和促进因素。
