Centeno Barbara A, Thomas Sarah C
Department of Pathology, Moffitt Cancer Center, Tampa, Florida, USA,
Department of Oncologic Sciences, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA,
Monogr Clin Cytol. 2020;26:42-52. doi: 10.1159/000455734. Epub 2020 Sep 28.
Benign non-neoplastic solid lesions of the pancreas are comprised of several separate entities, with their diagnostic identification best performed in correlation with the radiographic and clinical features. These include all of the pancreatitides, intrapancreatic spleen, and a few other rare entities. Preoperative imaging may suggest the correct diagnosis, but occasionally the preoperative imaging findings may be misleading because they overlap with those of pancreatic neoplasms. Masses associated with typical pancreatitides are rarely sampled due to their distinct clinical picture and relative frequency; however, the uncommon variants of pancreatitis may also present as mass lesions mimicking malignancy. Herein, we will discuss the cytopathologic findings of several solid pancreatic lesions, including acute pancreatitis, chronic pancreatitis, autoimmune pancreatitis, paraduodenal or groove pancreatitis, and other mass lesions, such as intrapancreatic accessory spleen and abscess. The key cytological features, ancillary studies, and differential diagnoses will also be discussed.
胰腺的良性非肿瘤性实性病变由几个不同的实体组成，最好结合影像学和临床特征进行诊断识别。这些包括所有类型的胰腺炎、胰腺内脾脏以及其他一些罕见实体。术前影像学检查可能提示正确诊断，但有时术前影像学检查结果可能会产生误导，因为它们与胰腺肿瘤的表现重叠。由于典型胰腺炎相关肿块具有独特的临床表现和相对发病率，很少对其进行采样；然而，胰腺炎的罕见变异型也可能表现为类似恶性肿瘤的肿块病变。在此，我们将讨论几种胰腺实性病变的细胞病理学表现，包括急性胰腺炎、慢性胰腺炎、自身免疫性胰腺炎、十二指肠旁或沟部胰腺炎以及其他肿块病变，如胰腺内副脾和脓肿。还将讨论关键的细胞学特征、辅助检查及鉴别诊断。
