Future Industries Institute, University of South Australia, Adelaide, SA 5000, Australia.
Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
Int J Mol Sci. 2020 Sep 24;21(19):7038. doi: 10.3390/ijms21197038.
The use of mesenchymal stem cells (MSC) for the treatment of cutaneous wounds is currently of enormous interest. However, the broad translation of cell therapies into clinical use is hampered by their efficacy, safety, manufacturing and cost. MSCs release a broad repertoire of trophic factors and immunomodulatory cytokines, referred to as the MSC secretome, that has considerable potential for the treatment of cutaneous wounds as a cell-free therapy. In this review, we outline the current status of MSCs as a treatment for cutaneous wounds and introduce the potential of the MSC secretome as a cell-free alternative for wound repair. We discuss the challenges and provide insights and perspectives for the future development of the MSC secretome as well as identify its potential clinical translation into a therapeutic treatment.
间充质干细胞（MSC）在皮肤创伤治疗中的应用目前受到广泛关注。然而，细胞疗法在临床应用中广泛推广受到其疗效、安全性、制造和成本的限制。MSC 释放了广泛的营养因子和免疫调节细胞因子，被称为 MSC 分泌组，作为一种无细胞疗法，它在皮肤创伤治疗方面具有巨大的潜力。在这篇综述中，我们概述了 MSC 作为皮肤创伤治疗方法的现状，并介绍了 MSC 分泌组作为无细胞替代物用于伤口修复的潜力。我们讨论了其中的挑战，并为 MSC 分泌组的未来发展提供了见解和观点，同时确定了其将潜在地转化为治疗性治疗的临床应用。
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