Ano Yasuhisa, Kobayashi Keiko, Hanyuda Mamoru, Kawashima Ryuta
Kirin Central Research Institute, Kirin Holdings Company, Ltd., Kanazawa-ku, Yokohama 236-0004, Japan.
Breast Health Clinic, Chuo-ku, Tokyo 103-0025, Japan.
Aging (Albany NY). 2020 Sep 29;12(18):18660-18675. doi: 10.18632/aging.103951.
The number of elderly individuals with age-related cognitive decline or dementia is rapidly increasing. Dairy product consumption, including β-lactolin, is beneficial for their cognitive function. The underlying mechanism of β-lactolin's effects on human brain activity is yet to be investigated. We examined the β-lactolin effects on human cerebral blood flow (CBF) using near-infrared spectroscopy (NIRS) in a placebo-controlled randomized double-blind study, which reported according to the CONSORT guidelines. Fifty healthy participants (aged 45-60 years) were randomly allocated into the β-lactolin or the placebo group (n = 25 each) and supplemented for 6 weeks. During the 6 week, oxy-hemoglobin during the working memory tasks was measured using 34-channels (CHs) NIRS. The changes of oxy-hemoglobin, which represents the CBF, in CH 23 located at the left dorsolateral prefrontal cortex (DLPFC) during the spatial working memory task showed higher statistical significance (false discovery rate () = 0.045) in the β-lactolin than in the placebo group. The oxy-Hb changes in CH23 have a co-relationship with the working memory task reaction time. This clinical trial showed an increase in the CBF in the left DLPFC area during the 6-week β-lactolin supplementation. This study contributes to elucidating the underlying mechanisms of β-lactolin on cognitive performance.
患有与年龄相关的认知衰退或痴呆症的老年人数量正在迅速增加。食用包括β-乳球蛋白在内的乳制品对他们的认知功能有益。β-乳球蛋白对人类大脑活动影响的潜在机制尚待研究。在一项根据CONSORT指南报告的安慰剂对照随机双盲研究中，我们使用近红外光谱（NIRS）研究了β-乳球蛋白对人脑血流量（CBF）的影响。50名健康参与者（年龄45 - 60岁）被随机分为β-乳球蛋白组或安慰剂组（每组n = 25），并进行了6周的补充。在这6周期间，使用34通道（CHs）NIRS测量工作记忆任务期间的氧合血红蛋白。在空间工作记忆任务期间，位于左背外侧前额叶皮层（DLPFC）的CH 23中代表CBF的氧合血红蛋白变化在β-乳球蛋白组中比安慰剂组具有更高的统计学意义（错误发现率（）= 0.045）。CH23中的氧合血红蛋白变化与工作记忆任务反应时间具有相关性。这项临床试验表明，在6周的β-乳球蛋白补充期间，左DLPFC区域的CBF增加。这项研究有助于阐明β-乳球蛋白对认知表现的潜在机制。
