The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia.
23andMe, Inc., Sunnyvale, CA, USA.
Nat Hum Behav. 2021 Jan;5(1):59-70. doi: 10.1038/s41562-020-00956-y. Epub 2020 Sep 28.
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (r = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.
利手性已被广泛研究，因为它与语言有关，并且左撇子在一些神经发育障碍中过度出现。我们使用来自英国生物银行、23andMe 和国际利手性联合会的数据，对利手性（N=1,766,671）进行了全基因组关联荟萃分析。我们发现 41 个与左利手相关的位点（P<5×10）和 7 个与双手灵巧性相关的位点。组织富集分析表明中枢神经系统在手性的发病机制中起作用。包括微管调节和大脑形态的途径也被强调。我们发现左利手与精神神经特质（包括精神分裂症和双相情感障碍）之间存在提示性的正遗传相关性。此外，左利手和双手灵巧性之间的遗传相关性较低（r=0.26），这意味着这些特质主要受不同遗传机制的影响。我们的研究结果表明，利手性是高度多基因的，导致左利手的遗传变异可能是某些精神障碍关联的部分原因。
