Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Department of Dermatology, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Mycoses. 2021 Jan;64(1):18-23. doi: 10.1111/myc.13190. Epub 2020 Oct 14.
Chromoblastomycosis (CBM) is a chronic granulomatous fungal infection caused by melanised or brown-pigmented fungi. It can lead to chronic persistent infections and may cause incapacity for labour in some severe clinical forms. The optimal therapy for CBM is still uncertain. Here, we reported the case of a 66-year-old male who has had red plaque and recurrent keratinised protrusions on his right forearm for 20 years. He was treated orally with terbinafine, itraconazole and isotretinoin. He also received carbon dioxide(CO ) laser to eradicate the keratinised protrusions and promote the penetration of photosensitiser. After the CO laser, 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) was adopted immediately to inhibiting the growth of fungi in subcutaneous tissue. The patient received an important improvement with a plaque and crust reduction after 4 months. For such recalcitrant case of chromoblastomycosis, the use of retinoid, CO laser combined with ALA-PDT may be a new adjuvant therapy. We further reviewed the cases of chromoblastomycosis treated with laser, photodynamic therapy or retinoic acid.
着色芽生菌病（CBM）是一种由黑色素或棕色色素真菌引起的慢性肉芽肿性真菌感染。它可导致慢性持续性感染，并可能在某些严重的临床形式中导致劳动能力丧失。CBM 的最佳治疗方法仍不确定。在这里，我们报告了一例 66 岁男性的病例，他的右前臂有红斑和复发性角化突起 20 年。他曾口服特比萘芬、伊曲康唑和异维 A 酸治疗。他还接受了二氧化碳（CO）激光治疗以消除角化突起并促进光敏剂的渗透。CO 激光后，立即采用基于 5-氨基酮戊酸的光动力疗法（ALA-PDT）抑制皮下组织中真菌的生长。经过 4 个月的治疗，患者的斑块和结痂减少，病情得到了显著改善。对于这种难治性着色芽生菌病病例，使用类视黄醇、CO 激光联合 ALA-PDT 可能是一种新的辅助治疗方法。我们进一步回顾了用激光、光动力疗法或视黄酸治疗的着色芽生菌病病例。
