Department of Dermatology, Nanfang Hospital, Southern Medical University, 1838 North Avenue, Guangzhou 510515, China.
Department of Dermatology, Nanfang Hospital, Southern Medical University, 1838 North Avenue, Guangzhou 510515, China.
Photodiagnosis Photodyn Ther. 2019 Jun;26:13-14. doi: 10.1016/j.pdpdt.2019.02.013. Epub 2019 Feb 12.
Chromoblastomycosis is a long-term fungal infection of the skin and subcutaneous tissue, usually presenting as partial hypertrophic and warty plaques. Effective treatment is necessary to control the development of lesions, especially in patients with associated diseases. But till now, the treatment is still a challenge. Photodynamic therapy (PDT) is an efficient and non-invasive treatment option. Here, we reported the case of a 52-year-old male with refractory chromoblastomycosis and leukopenia, who was successfully treated with 5-aminolevulinic acid-based PDT (ALA-PDT). A complete cure, confirmed by clinical improvement and mycological detection, was achieved after six sessions of every-other-week treatment. Post six months follow up no recurrence was observed. The case here suggests that ALA-PDT is a valuable anti-infective therapy for refractory chromoblastomycosis.
着色芽生菌病是一种皮肤和皮下组织的慢性真菌感染，通常表现为局部肥厚性和疣状斑块。为了控制病变的发展，特别是对于伴有相关疾病的患者，有效的治疗是必要的。但是到目前为止，治疗仍然是一个挑战。光动力疗法（PDT）是一种有效且非侵入性的治疗选择。在这里，我们报告了一例 52 岁男性患有难治性着色芽生菌病和白细胞减少症，他成功地接受了基于 5-氨基酮戊酸的光动力疗法（ALA-PDT）治疗。经过六次每两周一次的治疗，临床改善和真菌学检测均证实完全治愈。六个月的随访没有观察到复发。本病例表明，ALA-PDT 是治疗难治性着色芽生菌病的一种有价值的抗感染疗法。
