Nutritional Sciences Department, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Nutrition Research Center, Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Phytother Res. 2021 Feb;35(2):701-710. doi: 10.1002/ptr.6856. Epub 2020 Sep 29.
Propolis is a resinous substance produced by bees from plants. There has been some evidence indicating that propolis may be a candidate for the treatment of inflammatory bowel disease (IBD) because of its potent antioxidant properties and ability to modulate immune response and gut microbiome. The objective of this systematic review was to investigate the role of propolis in the treatment of IBD, emphasizing possible mechanisms underlying the anti-inflammatory properties of it. Searches were performed in ISI, PubMed/Medline, Scopus, EMBASE, and Cochrane Library databases up to March 2020. According to the studies examined in this review, the administration of propolis can be useful in attenuating many aspects of clinical, macroscopic, and histological features of colitis in animal models. The efficacy of propolis in the treatment of IBD might be attributed to its potent antioxidants and anti-inflammatory activities. Propolis may also be involved in the modulation of the gut microbiota and in the improvement of the intestinal mucosal barrier function. The major mechanism of action is most likely to be mediated via the prevention of some transcriptional factors and associated proteins. However, future studies are warranted to investigate the clinical utility of propolis as a candidate in the treatment of IBD.
蜂胶是蜜蜂从植物中提取的一种树脂状物质。有一些证据表明，蜂胶可能是治疗炎症性肠病（IBD）的候选药物，因为它具有强大的抗氧化特性，能够调节免疫反应和肠道微生物组。本系统评价的目的是研究蜂胶在治疗 IBD 中的作用，强调其抗炎特性的潜在机制。检索了 ISI、PubMed/Medline、Scopus、EMBASE 和 Cochrane Library 数据库，检索时间截至 2020 年 3 月。根据本综述中检查的研究，蜂胶的给药在减轻动物模型中结肠炎的许多临床、宏观和组织学特征方面可能是有用的。蜂胶在治疗 IBD 中的功效可能归因于其强大的抗氧化和抗炎活性。蜂胶还可能参与调节肠道微生物群，并改善肠道黏膜屏障功能。主要作用机制很可能是通过预防一些转录因子和相关蛋白来介导的。然而，需要进一步的研究来调查蜂胶作为治疗 IBD 的候选药物的临床应用。
