Hayes William J, Ferdinand Abigale, Neabore Stephan, Kappes John A, Hayes Katie M, Berendse Joseph
15488South Dakota State University, College of Pharmacy, Monument Health-Flormann Clinic, Rapid City, SD, USA.
Monument Health-Rapid City Hospital, Rapid City, SD, USA.
J Pharm Pract. 2022 Apr;35(2):298-301. doi: 10.1177/0897190020961229. Epub 2020 Sep 29.
Gabapentin is an analog of gamma-aminobutyric acid (GABA), but its complete mechanism is not well understood. Common adverse effects from gabapentin include somnolence, sedation, and dizziness. Hyperglycemia is listed as a possible adverse drug reaction in the labeling. Case reports describe hypoglycemia in patients with diabetes, peritoneal dialysis, and/or incomplete medication records. The following case report details a hypoglycemia episode as a potential result of a gabapentin use in a patient without diabetes.
A 47-year old, 68 kg, white female presented to the emergency department with altered mental status. Her blood glucose level was 33 mg/dL. Gabapentin was started 1 week prior to the hypoglycemia episode. Her past medical history, concomitant medications, and other laboratory findings were not likely causes of her severe hypoglycemia.
Gabapentin appears to have effects on several voltage-gated calcium channels. Hypoglycemia may be due to gabapentin binding to the alphadelta subunit of the calcium channels in the pancreas. Future research should investigate gabapentin and the potential for hypoglycemia.
加巴喷丁是γ-氨基丁酸（GABA）的类似物，但其完整机制尚不完全清楚。加巴喷丁常见的不良反应包括嗜睡、镇静和头晕。高血糖在药品标签中被列为可能的药物不良反应。病例报告描述了糖尿病患者、腹膜透析患者和/或用药记录不完整患者出现低血糖的情况。以下病例报告详细介绍了一名无糖尿病患者使用加巴喷丁后可能导致低血糖发作的情况。
一名47岁、体重68公斤的白人女性因精神状态改变被送往急诊科。她的血糖水平为33毫克/分升。在低血糖发作前1周开始使用加巴喷丁。她的既往病史、同时服用的药物以及其他实验室检查结果不太可能是导致她严重低血糖的原因。
加巴喷丁似乎对几种电压门控钙通道有影响。低血糖可能是由于加巴喷丁与胰腺中钙通道的αδ亚基结合所致。未来的研究应调查加巴喷丁及低血糖的可能性。
