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微血管减压术后三叉神经痛的管理:两例病例报告。

Trigeminal neuralgia management after microvascular decompression surgery: two case reports.

作者信息

Hwang Victor, Gomez-Marroquin Erick, Enciso Reyes, Padilla Mariela

机构信息

Master of Science Program in Orofacial Pain and Oral Medicine, Herman Ostrow School of Dentistry of USC, Los Angeles, California, USA.

Certificate Program in Orofacial Pain and Oral Medicine, Herman Ostrow School of Dentistry of USC, Los Angeles, California, USA.

出版信息

J Dent Anesth Pain Med. 2020 Dec;20(6):403-408. doi: 10.17245/jdapm.2020.20.6.403. Epub 2020 Dec 28.

DOI:10.17245/jdapm.2020.20.6.403
PMID:33409369
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7783379/
Abstract

Trigeminal neuralgia (TN) involves chronic neuropathic pain, characterized by attacks of repeating short episodes of unilateral shock-like pain, which are abrupt in onset and termination. Anticonvulsants, such as carbamazepine, are the gold standard first-line drugs for pharmacological treatment. Microvascular decompression (MVD) surgery is often the course of action if pharmacological management with anticonvulsants is unsuccessful. MVD surgery is an effective therapy in approximately 83% of cases. However, persistent neuropathic pain after MVD surgery may require reintroduction of pharmacotherapy. This case report presents two patients with persistent pain after MVD requiring reintroduction of pharmacological therapy. Although MVD is successful for patients with failed pharmacological management, it is an invasive procedure and requires hospitalization of the patient. About one-third of patients suffer from recurrent TN after MVD. Often, alternative treatment protocols, including the reintroduction of medications, may be necessary to achieve improvement. This case report presents two cases of post-MVD recurrent pain. Further research is lacking on the success rates of subsequent medication therapy after MVD has proven less effective in managing TN.

摘要

三叉神经痛(TN)涉及慢性神经性疼痛,其特征是单侧发作性短暂的电击样疼痛反复发作,发作和终止均很突然。抗惊厥药,如卡马西平,是药物治疗的金标准一线药物。如果抗惊厥药的药物治疗不成功,微血管减压术(MVD)通常是治疗方案。MVD手术在大约83%的病例中是一种有效的治疗方法。然而,MVD手术后持续的神经性疼痛可能需要重新引入药物治疗。本病例报告介绍了两名MVD手术后仍有持续性疼痛需要重新引入药物治疗的患者。虽然MVD对药物治疗失败的患者是成功的,但它是一种侵入性手术,需要患者住院治疗。大约三分之一的患者在MVD后会出现复发性TN。通常,可能需要包括重新用药在内的替代治疗方案才能实现病情改善。本病例报告介绍了两例MVD后复发性疼痛的病例。在MVD已被证明对治疗TN效果较差之后,后续药物治疗的成功率缺乏进一步研究。

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