Department of Chemistry, University of Wisconsin, 1101 University Avenue, Madison, Wisconsin 53706, United States.
J Am Chem Soc. 2020 Oct 14;142(41):17211-17223. doi: 10.1021/jacs.0c07347. Epub 2020 Sep 29.
The extraordinary rate accelerations and control of reactivity exhibited by enzymes have long inspired efforts to develop synthetic catalysts. Foldamers, which are oligomers with a strong tendency to adopt a specific conformation, represent unique platforms for efforts to harness principles of enzyme function for catalyst design. Well-defined helical structures that have been identified in several foldamer families can serve as scaffolds for the predictable spatial arrangement of functional groups. The chirality of these helices offers a basis for asymmetric catalysis. Thus, foldamer-based approaches to catalyst development represent an attractive alternative to well-developed strategies involving small molecules or conventional peptides.
酶所表现出的非凡速率加速和反应性控制长期以来激发了人们开发合成催化剂的努力。折叠物是一种具有强烈倾向于采用特定构象的低聚物，它们是利用酶功能原理进行催化剂设计的独特平台。已经在几个折叠物家族中确定的明确的螺旋结构可以作为功能基团可预测空间排列的支架。这些螺旋的手性为不对称催化提供了基础。因此，基于折叠物的催化剂开发方法是对涉及小分子或常规肽的成熟策略的一种有吸引力的替代方案。
