Li Jianming, Chen Yongjun, Xiang Qin, Xiang Ju, Tang Yonghong, Tang Liang
Department of Anatomy, Changsha Medical University.
Department of Rehabilitation, Xiangya Boai Rehabilitation Hospital, Changsha.
Medicine (Baltimore). 2020 Sep 25;99(39):e22319. doi: 10.1097/MD.0000000000022319.
Postpartum depression (PPD) is an episode of major depressive disorder that affecting women of childbearing age. 5-HTTLPR is 1 of the most extensively investigated polymorphisms in PPD. However, the previous results were inconsistent and inclusive. Hence, we performed a meta-analysis to precisely evaluate the association between 5-HTTLPR polymorphism and PPD susceptibility.
The studies were retrieved through databases including PubMed, web of science, EMASE, and CNKI. The odd ratios (ORs) and 95% confidence interval (CIs) were applied for evaluating the genetic association between 5-HTTLPR (L/S) polymorphism and PPD risk.
Six studies with 519 cases and 737 controls were enrolled in the present study. The frequencies of allelic (OR = 0.72, 95%CI = 0.60-0.85, P = .0001) and dominant (OR = 0.57, 95%CI = 0.44-0.73, P = .004) models of 5-HTTLPR polymorphism significantly decreased in patients with PPD than those in the healthy controls. Subgroup analysis based on ethnicity revealed that the allelic (OR = 0.71, 95%CI = 0.60-0.85, P = .0001) and dominant (OR = 0.51, 95%CI = 0.32-0.79, P = .003) models of 5-HTTLPR polymorphism were significantly associated with PPD risk in Asian population (P > .05). No evidence was observed between the recessive model of 5-HTTLPR polymorphism and PPD risk (P > .05).
The allelic and dominant models of 5-HTTLPR polymorphism might be protective factors for PPD. To confirm these results, larger number of association studies or multicenter case-control studies are necessary in the future.
产后抑郁症（PPD）是一种影响育龄女性的重度抑郁症发作。5-羟色胺转运体基因启动子区域多态性（5-HTTLPR）是PPD中研究最广泛的多态性之一。然而，先前的结果并不一致且存在争议。因此，我们进行了一项荟萃分析，以精确评估5-HTTLPR多态性与PPD易感性之间的关联。
通过包括PubMed、科学网、EMASE和中国知网在内的数据库检索研究。应用比值比（OR）和95%置信区间（CI）来评估5-HTTLPR（L/S）多态性与PPD风险之间的遗传关联。
本研究纳入了6项研究，共519例病例和737例对照。与健康对照组相比，PPD患者中5-HTTLPR多态性的等位基因模型（OR = 0.72，95%CI = 0.60 - 0.85，P = 0.0001）和显性模型（OR = 0.57，95%CI = 0.44 - 0.73，P = 0.004）的频率显著降低。基于种族的亚组分析显示，在亚洲人群中，5-HTTLPR多态性的等位基因模型（OR = 0.71，95%CI = 0.60 - 0.85，P = 0.0001）和显性模型（OR = 0.51，95%CI = 0.32 - 0.79，P = 0.003）与PPD风险显著相关（P > 0.05）。未观察到5-HTTLPR多态性隐性模型与PPD风险之间的关联证据（P > 0.05）。
5-HTTLPR多态性的等位基因和显性模型可能是PPD的保护因素。为证实这些结果，未来有必要进行更多的关联研究或多中心病例对照研究。
