Int J Oral Maxillofac Implants. 2020 Sep/Oct;35(5):917-923. doi: 10.11607/jomi.8082.
Compaction of particulated grafts is done manually; thus, the effect of compression force on bone regeneration remains unclear. The aim of this study was to evaluate the impact of two different compression forces on the consolidation of particulated bovine hydroxyapatite.
Two titanium cylinders were fixed on the calvarium of eight New Zealand rabbits. Both defects were filled with particulated bovine hydroxyapatite subjected to a compression force of 0.7 kg/cm or 1.6 kg/cm before being covered with a resorbable collagen membrane. A handheld device that uses a spring to control the compression force applied by the plugger was used. At 6 weeks, histomorphometry of the area immediately adjacent to the calvaria bone and to the collagen membrane was performed.
It was shown that next to the calvaria, the bone volume per tissue volume (BV/TV) was 29.0% ± 8.8% and 27.6% ± 8.2% at low and high compression force, respectively; the bone-to-biomaterial contact (BBC) was 58.2% ± 25.0% and 69.3% ± 22.9%, respectively (P > .05). In the corresponding area next to the collagen membrane, BV/TV was 4.9% ± 5.1% and 5.7% ± 4.7%, and the BBC was 18.3% ± 20.8% and 20.1% ± 15.9%, respectively (P > .05). In addition, the number and area of blood vessels were not significantly affected by compression force.
Both compression forces applied resulted in similar consolidation of bovine hydroxyapatite expressed by new bone formation and vascularization based on a rabbit calvaria augmentation model.
颗粒状移植物的压缩是手动进行的；因此，压缩力对骨再生的影响尚不清楚。本研究旨在评估两种不同压缩力对颗粒状牛羟磷灰石固结的影响。
将两个钛圆筒固定在 8 只新西兰兔的颅骨上。两个缺损均填充颗粒状牛羟磷灰石，然后在可吸收胶原膜下用 0.7 kg/cm2 或 1.6 kg/cm2 的压缩力进行压缩。使用一种手动装置，该装置使用弹簧控制插塞器施加的压缩力。6 周时，对颅骨骨和胶原膜附近的区域进行组织形态计量学分析。
结果表明，在颅骨旁，组织体积中的骨体积比（BV/TV）分别为低压缩力时的 29.0%±8.8%和高压缩力时的 27.6%±8.2%；骨-生物材料接触（BBC）分别为 58.2%±25.0%和 69.3%±22.9%（P＞0.05）。在相应的胶原膜旁区域，BV/TV 分别为 4.9%±5.1%和 5.7%±4.7%，BBC 分别为 18.3%±20.8%和 20.1%±15.9%（P＞0.05）。此外，血管数量和面积不受压缩力的显著影响。
基于兔颅骨增强模型，两种施加的压缩力均导致牛羟磷灰石的相似固结，表现为新骨形成和血管化。
