Centro Singular de Investigación en Química Biolóxica e Materiais, Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Instituto de Química Orgánica General (CSIC), Juan de la Cierva 3, 28006, Madrid, Spain.
Chemistry. 2021 Mar 12;27(15):4789-4816. doi: 10.1002/chem.202003927. Epub 2021 Jan 12.
During the last decade, there has been a tremendous interest for developing non-natural biocompatible transformations in biologically relevant media. Among the different encountered strategies, the use of transition metal complexes offers unique possibilities due to their high transformative power. However, translating the potential of metal catalysts to biological settings, including living cells or small-animal models such as mice or zebrafish, poses numerous challenges associated to their biocompatibility, and their stability and reactivity in crowded aqueous environments. Herein, we describe the most relevant advances in this direction, with a particular emphasis on the systems' structure, their mode of action and the mechanistic bases of each transformation. Thus, the key challenges from an organometallic perspective might be more easily identified.
在过去的十年中，人们对在生物相关介质中开发非天然生物相容性转化产生了浓厚的兴趣。在遇到的不同策略中，过渡金属配合物的使用由于其强大的转化能力提供了独特的可能性。然而，将金属催化剂的潜力转化为生物环境，包括活细胞或小型动物模型，如老鼠或斑马鱼，会带来与其生物相容性以及它们在拥挤的水相环境中的稳定性和反应性相关的诸多挑战。本文中，我们描述了这一方向的最重要进展，特别强调了系统的结构、作用模式以及每种转化的机械基础。因此，从有机金属的角度来看，关键的挑战可能更容易被识别。
