将生物催化与化学催化相结合进行选择性转化。
Integrating biocatalysis with chemocatalysis for selective transformations.
机构信息
Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Departments of Chemistry, Biochemistry, and Bioengineering, Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
出版信息
Curr Opin Chem Biol. 2020 Apr;55:161-170. doi: 10.1016/j.cbpa.2020.02.004. Epub 2020 Mar 13.
The integration of biocatalysis with chemocatalysis combines the excellent selectivity of the former with the robust reactivity of the latter and offers many advantages, such as lower cost, higher yield, enhanced selectivity, as well as less waste generation. In spite of the challenge of incompatibilities between different classes of catalysts, recent advances in synthetic chemistry and biology provide ample opportunities for multistep cascade transformations that combine biocatalysis and chemocatalysis. Herein, we review recent progress in merging biocatalysis with chemocatalysis, highlighting selected examples of photo-/electricity-driven biotransformations and recently developed strategies for addressing the catalyst incompatibility issue.
生物催化与化学催化的结合结合了前者的优异选择性和后者的强反应性，并具有许多优势，例如降低成本、提高产率、增强选择性以及减少废物产生。尽管不同类别的催化剂之间存在不兼容性的挑战，但合成化学和生物学的最新进展为结合生物催化和化学催化的多步级联转化提供了充足的机会。在此，我们综述了近年来将生物催化与化学催化相结合的最新进展，重点介绍了光/电驱动生物转化的一些实例以及最近开发的解决催化剂不兼容性问题的策略。
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