Sarno A P, Miller E J, Lundblad E G
Obstet Gynecol. 1987 Jul;70(1):33-6.
Danazol (200 mg/day) or placebo was administered to patients with premenstrual syndrome from the onset of symptoms until the onset of menses, for two cycles each, in a prospective, double-blind, crossover design. Eleven of 14 patients improved on danazol. The symptom scores with danazol were significantly lower than those with placebo (P less than .035). No side effects were reported from the medication. We conclude that danazol, given periodically and in a relatively low dose, appears to have a beneficial effect in the treatment of premenstrual syndrome.
采用前瞻性、双盲、交叉设计，在经前期综合征患者出现症状至月经来潮期间，给予达那唑（200毫克/天）或安慰剂，各治疗两个周期。14例患者中有11例使用达那唑后症状改善。达那唑治疗后的症状评分显著低于安慰剂组（P<0.035）。未报告该药物有副作用。我们得出结论，定期给予相对低剂量的达那唑似乎对经前期综合征的治疗有有益作用。
