Day J
Postgrad Med J. 1979;55 Suppl 5:87-9.
Danazol as a powerful antigonadotrophin is a logical mode of treatment for patients with premenstrual symptoms. Its preliminary use in a dose 200-800 mg daily is reported. Two groups of patients were treated and of 12 patients with severe symptoms (Group I) six benefited from treatment. The second group (Group II) presenting as fresh cases were given 400 mg daily as the first or second choice of treatment. This group had a high drop out rate and any benefit from treatment was marred by the side effects. Danazol will continue to be used where the symptoms are resistant to other treatment, especially when breast tenderness is predominant. The dose should be the minimum required for relief of symptoms.
达那唑作为一种强效抗促性腺激素药物，是治疗经前症状患者的合理治疗方式。据报道，其初步使用剂量为每日200 - 800毫克。对两组患者进行了治疗，12名症状严重的患者（第一组）中有6名从治疗中获益。第二组（第二组）为新病例，作为首选或次选治疗方案，每日给予400毫克。该组患者退出率高，治疗带来的任何益处都被副作用所抵消。在症状对其他治疗有抵抗性时，尤其是乳房压痛占主导时，达那唑将继续使用。剂量应为缓解症状所需的最小剂量。
