Watts J F, Butt W R, Logan Edwards R
Br J Obstet Gynaecol. 1987 Jan;94(1):30-4. doi: 10.1111/j.1471-0528.1987.tb02248.x.
Forty women with premenstrual tension received either placebo, 100, 200 or 400 mg danazol daily for 3 months in a pilot study arranged as a double-blind trial. Thirteen patients withdrew by the third month usually because they complained of no improvement. They had significantly higher pretrial symptom scores than those who continued. In patients treated with danazol, symptom scores for breast pain during the second and third months and for irritability, anxiety and lethargy during the third month were significantly (P less than 0.05) lower than scores in those given placebo. Most symptoms improved on placebo in the first month but by the third month only three remained improved. In contrast eight symptoms were improved on 200 mg danazol by the third month. By the end of the trial more than 75% of patients who were still taking danazol were essentially free of breast pain, lethargy, anxiety and increased appetite, but results for other common symptoms were no better than with placebo.
在一项安排为双盲试验的初步研究中，40名患有经前紧张症的女性被给予安慰剂、每日100毫克、200毫克或400毫克达那唑，为期3个月。到第三个月时，有13名患者退出，通常是因为她们抱怨没有改善。她们在试验前的症状评分明显高于继续治疗的患者。在接受达那唑治疗的患者中，第二个月和第三个月乳房疼痛的症状评分，以及第三个月易怒、焦虑和无精打采的症状评分，均显著低于服用安慰剂的患者（P小于0.05）。大多数症状在第一个月服用安慰剂时有所改善，但到第三个月时只有三种症状仍有改善。相比之下，到第三个月时，服用200毫克达那唑有八种症状得到改善。到试验结束时，仍在服用达那唑的患者中，超过75%的患者基本没有乳房疼痛、无精打采、焦虑和食欲增加的症状，但其他常见症状的结果并不比服用安慰剂更好。
