Hojo Takayuki, Kimura Yukifumi, Ohiwa Daisuke, Fujisawa Toshiaki
Department of Dental Anesthesiology, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan.
Department of Dental Anesthesiology and Perioperative Management, Hinode Makomanai Dental Hospital, Sapporo, Japan.
Anesth Prog. 2020 Sep 1;67(3):170-171. doi: 10.2344/anpr-67-03-06.
This is a case report of methemoglobinemia presumably caused by the combined use of prilocaine (propitocaine) and nitroglycerin under general anesthesia. Methemoglobinemia is reportedly caused by the administration of prilocaine at a dose of ≥8 mg/kg. Moreover, ≥3 μg/kg/min of nitroglycerin can also trigger methemoglobinemia. In this patient, methemoglobinemia occurred despite neither drug having been administered at the aforementioned doses. Even if individual doses of drugs predisposed to causing methemoglobinemia are low, combined use may increase the risk of methemoglobinemia.
这是一篇关于高铁血红蛋白血症的病例报告，推测其由全身麻醉下联合使用丙胺卡因（丙氧卡因）和硝酸甘油所致。据报道，丙胺卡因剂量≥8mg/kg时可引发高铁血红蛋白血症。此外，硝酸甘油剂量≥3μg/kg/min也可引发高铁血红蛋白血症。在该患者中，尽管两种药物均未达到上述剂量，但仍发生了高铁血红蛋白血症。即使导致高铁血红蛋白血症的单一药物剂量较低，联合使用也可能增加高铁血红蛋白血症的风险。
