Suragimath Girish, Patil Satish, Suragimath Disha G, Sr Ashwinirani
Periodontology, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.
Microbiology, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.
Cureus. 2024 Nov 25;16(11):e74381. doi: 10.7759/cureus.74381. eCollection 2024 Nov.
Salivaomics has emerged as a ground-breaking field in the detection and management of oral cancer (OC), offering a non-invasive, efficient, and patient-friendly alternative to traditional diagnostic methods. This innovative approach leverages the comprehensive molecular insights provided by genomics, transcriptomics, proteomics, metabolomics, and microbiomics. The potential of salivaomics lies in its ability to enable early detection, predict malignant transformation, and monitor treatment outcomes and disease recurrence. Advancing salivary diagnostics necessitates the standardization of saliva collection and processing protocols, identification and validation of robust biomarkers, and development of cutting-edge detection technologies. A single biomarker is unlikely to fulfill all diagnostic requirements; thus, research should focus on developing a panel of biomolecules to enhance diagnostic accuracy and management of OC. Salivaomics stands at the forefront of non-invasive diagnostic methods, with the promise to revolutionize early detection and management of OC. Future research directions should emphasize the integration of multi-omics data for superior biomarker discovery, the development of portable and cost-effective point-of-care devices, and the fostering of interdisciplinary collaborations to drive innovation. Overcoming these challenges will facilitate the translation of salivaomics into routine clinical practice, significantly improving early diagnosis, treatment, and prognosis of OC. This review provides a comprehensive overview of salivaomics, detailing the use of saliva as a diagnostic fluid. It covers saliva collection, preparation, transportation, storage methods, and various analytical techniques. Additionally, the review discusses the current challenges and future directions of this transformative technology, emphasizing its potential to enhance clinical outcomes in OC.
唾液组学已成为口腔癌（OC）检测与管理领域的一个开创性领域，为传统诊断方法提供了一种非侵入性、高效且患者友好的替代方案。这种创新方法利用了基因组学、转录组学、蛋白质组学、代谢组学和微生物组学提供的全面分子见解。唾液组学的潜力在于其能够实现早期检测、预测恶性转化以及监测治疗效果和疾病复发。推进唾液诊断需要唾液采集和处理方案的标准化、强大生物标志物的识别与验证以及前沿检测技术的开发。单一生物标志物不太可能满足所有诊断要求；因此，研究应专注于开发一组生物分子以提高OC的诊断准确性和管理水平。唾液组学处于非侵入性诊断方法的前沿，有望彻底改变OC的早期检测和管理。未来的研究方向应强调整合多组学数据以发现更优质的生物标志物、开发便携式且经济高效的即时检测设备，以及促进跨学科合作以推动创新。克服这些挑战将有助于将唾液组学转化为常规临床实践，显著改善OC的早期诊断、治疗和预后。本综述全面概述了唾液组学，详细介绍了唾液作为诊断液的用途。它涵盖了唾液采集、制备、运输、储存方法以及各种分析技术。此外，该综述讨论了这项变革性技术当前面临的挑战和未来方向，强调了其在改善OC临床结果方面的潜力。
