Department of Surgery, Medical, Molecular, and Critical Area, University of Pisa, 56126 Pisa, Italy.
Department of Endocrinology and Nutrition, Cliniques Universitaires Saint Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium.
Nutrients. 2020 Sep 25;12(10):2940. doi: 10.3390/nu12102940.
This study assessed the effects of weekly vitamin D (VD) supplementation on clinical and biological parameters after scaling and root planning (SRP) in the treatment of periodontitis and served to validate the VD dosage regimen.
It was a monocentric, randomized, double-blind, placebo-controlled clinical trial with 6 months follow-up. Healthy Caucasian periodontitis patients presenting serum 25(OH) vitamin D3 below 30 ng/mL were randomly allocated to test group (SRP + VD 25,000 international units (IU)/week) or the control group (SRP + placebo).
A total of 59 patients were screened, 27 were included and 26 completed 3 months (M) and 21 completed 6M control. Test ( = 13) and control groups ( = 14) had similar 25(OH) vitamin D3 levels at baseline (17.6 ± 7.4 vs. 14.4 ± 5.2, respectively). After one month, there was a significant difference between groups (32.9 ± 5.2 vs. 16.1 ± 4.7), also seen at M3 and M6 (-test, < 0.001). Periodontal treatment was successful in both groups, since it resulted in a reduction of all measured clinical parameters at M3 and M6 (probing pocket depth (PPD), full mouth bleeding and plaque). However, the reduction in PPD was greater in the test group.
In this short-term pilot study, no significant differences were observed between two groups. However, supplementation with VD tended to improve the treatment of periodontitis in patients with initial 25(OH) vitamin D3 < 30 ng/mL and proved safe and efficacious. NCT03162406.
本研究评估了在牙周炎治疗中，每周补充维生素 D（VD）对临床和生物学参数的影响，并验证了 VD 剂量方案。
这是一项单中心、随机、双盲、安慰剂对照的临床试验，随访 6 个月。健康的白种人牙周炎患者血清 25(OH) 维生素 D3 水平低于 30ng/mL 时，随机分为试验组（SRP+VD 25000IU/周）或对照组（SRP+安慰剂）。
共筛选了 59 例患者，27 例入选，26 例完成 3 个月（M）和 21 例完成 6 个月对照。试验组（ = 13）和对照组（ = 14）在基线时 25(OH) 维生素 D3 水平相似（分别为 17.6 ± 7.4ng/mL 和 14.4 ± 5.2ng/mL）。一个月后，两组之间有显著差异（32.9 ± 5.2ng/mL 和 16.1 ± 4.7ng/mL），M3 和 M6 时也存在差异（ -检验，<0.001）。两组牙周治疗均成功，因为 M3 和 M6 时所有测量的临床参数均降低（探诊深度（PPD）、全口出血和菌斑）。然而，试验组的 PPD 降低幅度更大。
在这项短期的初步研究中，两组之间没有观察到显著差异。然而，VD 补充剂可能会改善初始 25(OH) 维生素 D3<30ng/mL 的患者的牙周炎治疗效果，且安全有效。NCT03162406。
