Ziada Saida, Wishahe Aws, Mabrouk Najet, Sahtout Souad
Department of Restorative Dentistry and Endodontics, Faculty of Dental Medicine, University of Monastir, Monastir, Tunisia.
BMC Oral Health. 2025 Apr 1;25(1):468. doi: 10.1186/s12903-025-05883-w.
Vitamin D (VD) levels are gaining increasing interest in dentistry due to their association with several oral diseases.
This study aimed to evaluate the relationship between vitamin D deficiency and various oral disorders.
A broad search on the MEDLINE database via the PubMed interface and on the Spring Link platform was carried out using keywords related to the subject. An additional electronic search of gray literature was conducted via Google Scholar. Inclusion criteria were listed for the selection of articles and a reading grid was designed for the extraction of data relating to the research question. The quality of included studies was assessed using JBI's critical appraisal tools.
A total of 57 studies were identified. After reading the full text, 16 studies were included and selected for qualitative analysis. There is an association between vitamin D deficiency and different oral disorders. Indeed, ten publications assessed the association between vitamin deficiency and periodontal disease, three examined the relationship between vitamin D deficit and dental caries, and one examined the intriguing relationship between vitamin D deficiency and tooth mineralization and two articles interested in vitamin D deficiency and stomatitis.
The analysis of these selected articles shows that Vitamin D deficiency can lead to various oral health disorders during growth and adulthood. Indeed, it can be linked to tooth mineralization defects and increasing the risk of dental caries. Severe Vitamin D deficiency also increases the prevalence of periodontitis and gingival inflammation. It may also be linked to certain oral pathology entities, such as oral cancers and jaw osteonecrosis.
由于维生素D（VD）与多种口腔疾病相关，其在牙科领域越来越受到关注。
本研究旨在评估维生素D缺乏与各种口腔疾病之间的关系。
通过PubMed界面在MEDLINE数据库以及Spring Link平台上使用与该主题相关的关键词进行广泛搜索。还通过谷歌学术对灰色文献进行了额外的电子搜索。列出了文章选择的纳入标准，并设计了一个阅读网格用于提取与研究问题相关的数据。使用JBI的批判性评价工具评估纳入研究的质量。
共识别出57项研究。阅读全文后，纳入16项研究并选择进行定性分析。维生素D缺乏与不同的口腔疾病之间存在关联。确实，十篇出版物评估了维生素缺乏与牙周病之间的关联，三篇研究了维生素D缺乏与龋齿之间的关系，一篇研究了维生素D缺乏与牙齿矿化之间的有趣关系，还有两篇文章关注维生素D缺乏与口腔炎。
对这些选定文章的分析表明，维生素D缺乏在生长和成年期可导致各种口腔健康问题。确实，它可能与牙齿矿化缺陷有关，并增加龋齿风险。严重的维生素D缺乏还会增加牙周炎和牙龈炎症的患病率。它也可能与某些口腔病理实体有关，如口腔癌和颌骨坏死。
