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基于新一代测序的临床宏基因组学在一名患有大量类肺炎性胸腔积液且胸腔积液培养结果为阴性的糖尿病青少年中的应用：一例报告

Next-generation sequencing-based clinical metagenomics identifies in a diabetic adolescent with large parapneumonic effusion and negative growth of pleural fluid culture: a case report.

作者信息

Galliguez T, Tsou P Y, Cabrera A, Fergie J

机构信息

Department of Pediatrics, Driscoll Children's Hospital and College of Medicine, Texas A&M University , Corpus Christi, TX, USA.

出版信息

Br J Biomed Sci. 2021 Apr;78(2):101-105. doi: 10.1080/09674845.2020.1827846. Epub 2021 Jan 13.

DOI:10.1080/09674845.2020.1827846
PMID:32993476
Abstract

We report a 12-year-old diabetic boy with a right-sided parapneumonic effusion and pneumonia who failed initial empirical antibiotics. was identified from the pleural fluid using next-generation sequencing-based clinical metagenomics with cultures of pleural fluid and blood resulting negative. The patient responded well to intravenous meropenem followed by oral metronidazole.

摘要

我们报告了一名12岁的糖尿病男孩，他患有右侧肺炎旁胸腔积液和肺炎，初始经验性抗生素治疗失败。通过基于下一代测序的临床宏基因组学从胸腔积液中鉴定出病原体，而胸腔积液和血液培养结果均为阴性。患者静脉注射美罗培南后改用口服甲硝唑，治疗效果良好。

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Next-generation sequencing-based clinical metagenomics identifies in a diabetic adolescent with large parapneumonic effusion and negative growth of pleural fluid culture: a case report.基于新一代测序的临床宏基因组学在一名患有大量类肺炎性胸腔积液且胸腔积液培养结果为阴性的糖尿病青少年中的应用：一例报告
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