Guangxi Engineering Center in Biomedical Material for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
Guangxi Collaborative Innovation Center for Biomedicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
J Nanobiotechnology. 2020 Sep 29;18(1):139. doi: 10.1186/s12951-020-00694-3.
Drug therapy of osteoarthritis (OA) is limited by the short retention and lacking of stimulus-responsiveness after intra-articular (IA) injection. The weak acid microenvironment in joint provides a potential trigger for controlled drug release systems in the treatment of OA. Herein, we developed an pH-responsive metal - organic frameworks (MOFs) system modified by hyaluronic acid (HA) and loaded with an anti-inflammatory protocatechuic acid (PCA), designated as MOF@HA@PCA, for the therapy of OA. Results demonstrated that MOF@HA@PCA could smartly respond to acidic conditions in OA microenvironment and gradually release PCA, which could remarkably reduce synovial inflammation in both IL-1β induced chondrocytes and the OA joints. MOF@HA@PCA also down-regulated the expression of inflammatory markers of OA and promoted the expression of cartilage-specific makers. This work may provide a new insight for the design of efficient nanoprobes for precision theranostics of OA .
骨关节炎（OA）的药物治疗受到限制，因为关节内（IA）注射后药物的保留时间短且缺乏刺激反应性。关节中的弱酸性微环境为治疗 OA 的控制药物释放系统提供了一个潜在的触发因素。在此，我们开发了一种由透明质酸（HA）修饰并负载具有抗炎作用的原儿茶酸（PCA）的 pH 响应型金属-有机骨架（MOF）系统，命名为 MOF@HA@PCA，用于 OA 的治疗。结果表明，MOF@HA@PCA 可以智能地响应 OA 微环境中的酸性条件，并逐渐释放 PCA，这可以显著减轻 IL-1β 诱导的软骨细胞和 OA 关节中的滑膜炎症。MOF@HA@PCA 还下调了 OA 的炎症标志物的表达，并促进了软骨特异性标志物的表达。这项工作可能为设计用于 OA 精准治疗的高效纳米探针提供了新的思路。
