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古巴的 COVID-19 与癌症

COVID-19 and Cancer in Cuba.

机构信息

Cancer Control Division, Ministry of Health, La Habana, CP, Cuba.

Clinical Research Division, Center of Molecular Immunology, Havana, Cuba.

出版信息

Semin Oncol. 2020 Oct;47(5):328-329. doi: 10.1053/j.seminoncol.2020.07.009. Epub 2020 Aug 7.

DOI:10.1053/j.seminoncol.2020.07.009
PMID:32994047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7413158/
Abstract

The COVID-19 pandemic has called attention to the contribution of comorbidities, including cancer and brought additional challenges to previously existing programs for cancer treatment and control. The COVID-19 pandemic in Cuba was addressed through an integrated all-society action plan that to date has been largely successful with a low incidence of COVID-19 and mortality rates several-fold lower than worldwide averages. Despite downsizing many other health components all oncology services were maintained. Between March 11, when the first case was detected, until July 23, Cuba reported 2,449 cases of COVID-19 that included 28 (1.14%) with a diagnosis of cancer. Distribution among cancer diagnoses did not deviate from that expected according to cancer epidemiology in Cuba. However, although the probability of getting infected with the coronavirus for a cancer patient (0.012%), was not higher than that of the general population (0.020%), 9 of the 28 (32.1%) died, a lethality higher than that of COVID-19 patients without cancer (3.5%) a difference that is statistically significant (P< .001). We argue that going forward scientific research on the relationship of aging, inflammation and cancer, including identification of biomarkers and the development of novel therapeutic interventions, should become one of the priorities in the post-COVID agenda of both oncologists and infectious disease scientists.

摘要

新型冠状病毒肺炎(COVID-19)大流行引起了人们对合并症(包括癌症)的关注,并给以前存在的癌症治疗和控制计划带来了额外的挑战。古巴通过一项综合的全社会行动计划应对 COVID-19 疫情,该计划迄今为止取得了很大成功,COVID-19 发病率低,死亡率比全球平均水平低数倍。尽管大幅削减了许多其他卫生部门的预算,但所有肿瘤学服务都得以维持。自 3 月 11 日首次发现病例至 7 月 23 日,古巴报告了 2449 例 COVID-19 病例,其中 28 例(1.14%)诊断为癌症。根据古巴的癌症流行病学,癌症诊断的分布与预期相符。然而,尽管癌症患者感染冠状病毒的概率(0.012%)并不高于普通人群(0.020%),但 28 例中有 9 例(32.1%)死亡,其死亡率高于无癌症的 COVID-19 患者(3.5%),差异具有统计学意义(P<.001)。我们认为,今后应将老龄化、炎症和癌症之间关系的科学研究,包括识别生物标志物和开发新的治疗干预措施,作为肿瘤学家和传染病学家在 COVID-19 后议程中的优先事项之一。

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本文引用的文献

1
Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study.COVID-19 对癌症患者的临床影响(CCC19):一项队列研究。
Lancet. 2020 Jun 20;395(10241):1907-1918. doi: 10.1016/S0140-6736(20)31187-9. Epub 2020 May 28.
2
Biomodulina T partially restores immunosenescent CD4 and CD8 T cell compartments in the elderly.Biomodulina T 部分恢复老年免疫衰老的 CD4 和 CD8 T 细胞区室。
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Back and forth between cancer treatment and cancer control programs: Insights from the Cuban experience.在癌症治疗和癌症控制项目之间来回切换:来自古巴经验的见解。
Semin Oncol. 2018 Jan;45(1-2):12-17. doi: 10.1053/j.seminoncol.2018.04.004. Epub 2018 Apr 30.
5
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