Prakash Sadanand, Agrawal Manas Mani, Kumar Rajendra, Yadav Shubhangi
Department of Radiation Oncology, King George's Medical University, Lucknow.
Department of Anatomy, All India Institute of Medical Sciences, Raebareli.
Monaldi Arch Chest Dis. 2020 Nov 27;90(4). doi: 10.4081/monaldi.2020.1357.
A worldwide outbreak of a respiratory illness, first detected in December 2019 in Wuhan city, Hubei province, China is ongoing. The disease is caused by a novel coronavirus, SARS-CoV-2 and on February 11, 2020, was officially named Coronavirus Disease 2019 (COVID-19) by the World Health Organization. Within few weeks, it has spread globally to the extent that World Health Organization declared it as a global pandemic on March 11, 2020. India's first positive case was reported on January 30th in Kerala. Before March 3rd, India had 3 cases of coronavirus in Kerala all of which were treated and discharged. On March 3rd, India's 4th case was diagnosed in the state of Rajasthan. Indian government had announced a number of preventive measures to minimize the entry and spread of coronavirus. On March 3rd, India announced the suspension of all visas issued to Italy, Iran, South Korea and Japan. India banned international flights from March 22nd. A 21-day lockdown across the country was imposed from March 26th, which later got further extended. Rigorous contact tracing and tracking of COVID patients and monitoring home quarantine helped in preventing community transmission. The aim of this work is to describe the experience with clinical and epidemiologic features, as well as with the management of COVID-19 patients in north India. This is a descriptive study of the 17 COVID-19 infected patients confirmed with polymerase chain reaction (PCR) and admitted to a tertiary care centre in India from March 11th 2020 to April 16th 2020. The present work also provides insight in to treatment provided and final outcome of the patients infected with COVID-19 in India. Laboratory investigations in COVID-19 patients in the Indian subcontinent reveal lymphopenia as predominant finding in hemogram. Patients with older age and associated comorbidities (COPD, hypertension and diabetes) seem to have greater risk for lung injury, thereby requiring oxygen support during the course of disease.
一种呼吸道疾病正在全球范围内爆发，该疾病于2019年12月在中国湖北省武汉市首次被发现。这种疾病由一种新型冠状病毒——严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起，并于2020年2月11日被世界卫生组织正式命名为2019冠状病毒病（COVID-19）。在短短几周内，它已在全球范围内传播，以至于世界卫生组织于2020年3月11日宣布其为全球大流行疾病。印度的首例阳性病例于1月30日在喀拉拉邦被报告。在3月3日之前，印度喀拉拉邦有3例冠状病毒病例，所有患者均接受治疗并出院。3月3日，印度拉贾斯坦邦确诊了第4例病例。印度政府宣布了多项预防措施，以尽量减少冠状病毒的传入和传播。3月3日，印度宣布暂停向意大利、伊朗、韩国和日本发放所有签证。印度从3月22日起禁止国际航班。3月26日起在全国范围内实施了为期21天的封锁，后来封锁期限进一步延长。对COVID患者进行严格的接触者追踪和监测，以及对居家隔离进行监控，有助于防止社区传播。这项工作的目的是描述印度北部COVID-19患者的临床和流行病学特征以及管理经验。这是一项对2020年3月11日至2020年4月16日期间在印度一家三级护理中心住院的17例经聚合酶链反应（PCR）确诊感染COVID-19的患者进行的描述性研究。本研究还深入了解了印度COVID-19感染患者所接受的治疗及最终结果。对印度次大陆COVID-19患者的实验室检查显示，血常规中淋巴细胞减少是主要发现。年龄较大且伴有合并症（慢性阻塞性肺疾病、高血压和糖尿病）的患者似乎肺部损伤风险更高，因此在病程中需要氧气支持。
