极低出生体重儿应在生后 2 周内给予全肠内营养。
Very low birth weight infants receive full enteral nutrition within 2 postnatal weeks.
机构信息
Department of Pediatrics, Medical University of South Carolina, 10 McClennan Banks Drive, MSC 915, Charleston, SC, 29425, USA.
Department of Medicine, Medical University of South Carolina, 114 Doughty Street, Charleston, SC, 29425, USA.
出版信息
J Perinatol. 2020 Dec;40(12):1849-1856. doi: 10.1038/s41372-020-00819-4. Epub 2020 Sep 29.
OBJECTIVE
Identify whether an enteral nutrition goal of reaching full feeds by 7 postnatal days for infants 1-1.5 kg and by 14 postnatal days for infants <1 kg was feasible and its associated outcomes.
STUDY DESIGN
Very low birth weight infant cohort admitted in the first postnatal day and categorized as either Epoch 1 or Epoch 2, 12 months before and after implementation of a revised feeding protocol were compared.
RESULT
In Epoch 2, 83% infants born 1-1.5 kg and 77% infants born <1 kg reached full feeds by 7 and 14 days compared to 26% and 25%, respectively in Epoch 1 (p < 0.0001). Central line and parental nutrition days were significantly lower in Epoch 2 compared to Epoch 1 with sustained and potentially improved infant growth.
CONCLUSION
An evidence-based advancement feeding protocol was associated with achieving full feeds within the first 2 postnatal weeks for very low birth weight infants.
目的
确定 1-1.5kg 体重的婴儿在出生后 7 天内达到全肠内营养，而体重 <1kg 的婴儿在出生后 14 天内达到全肠内营养的目标是否可行及其相关结果。
研究设计
比较实施修订喂养方案前 12 个月（Epoch1）和后 12 个月（Epoch2）的极低出生体重儿队列，这些婴儿在出生后第一天入院，并分为 Epoch1 或 Epoch2。
结果
在 Epoch2 中，83%体重 1-1.5kg 的婴儿和 77%体重 <1kg 的婴儿在 7 天和 14 天达到全肠内营养，而在 Epoch1 中，分别只有 26%和 25%达到（p<0.0001）。与 Epoch1 相比，Epoch2 中的中心静脉置管和父母营养天数明显减少，且婴儿的生长得到持续和潜在的改善。
结论
一项基于证据的先进喂养方案与极低出生体重儿在出生后前 2 周内达到全肠内营养有关。
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