Huo Jinxi, Sun Yuqing, Zhong Shi, Li Yougui, Yang Ruchun, Xia Lijuan, Wang Jiahong, Zhang Majuan, Zhu Jianxun
Sericultural Research Institute Zhejiang Academy of Agricultural Sciences Hangzhou China.
Hangzhou Hospital of Traditional Chinese Medicine Hangzhou China.
Food Sci Nutr. 2020 Aug 5;8(9):5107-5113. doi: 10.1002/fsn3.1811. eCollection 2020 Sep.
, called "Sanghuang," is orally used for health care, tumor, and inflammation treatment in Asia. However, the safety of has not been evaluated. The major compounds analysis showed that aqueous extracts of fruiting body were rich in polysaccharides, nucleotides, and polyphenols. Then, the aqueous was given orally to Sprague-Dawley rats for toxical test. In acute toxicity study, the maximum tolerated dose was 21 g/kg. In 17-week repeated dose toxicity experiment, all rats had no abnormal reaction among control group, low dose group (0.15 g/kg) and middle dose group (1.00 g/kg). At high dose group (6.00 g/kg), the feces began to darken on 16th day (D16), and turned to drug stained stool on D21, all rats recovered on the 3rd day (D92) of recovery period. During the whole experiment, there were no animal death and no treatment-related changes in any of the parameters under the all doses. These results indicated the No-Observed Adverse Effect Level of aqueous extract of fruiting body was 1.0 g/kg.
在亚洲，被称为“桑黄”的[物质名称未给出]被口服用于保健、肿瘤和炎症治疗。然而，[物质名称未给出]的安全性尚未得到评估。主要化合物分析表明，[物质名称未给出]子实体的水提取物富含多糖、核苷酸和多酚。然后，将该水提取物口服给予斯普拉格-道利大鼠进行毒性试验。在急性毒性研究中，最大耐受剂量为21 g/kg。在为期17周的重复剂量毒性实验中，对照组、低剂量组（0.15 g/kg）和中剂量组（1.00 g/kg）的所有大鼠均无异常反应。在高剂量组（6.00 g/kg），第16天（D16）粪便开始变黑，第21天变为药物染色粪便，所有大鼠在恢复期第3天（D92）恢复。在整个实验过程中，所有剂量下均无动物死亡，任何参数均无与治疗相关的变化。这些结果表明，[物质名称未给出]子实体水提取物的未观察到不良反应水平为1.0 g/kg。
