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桑黄提取物延长了DAF-16/SIR-2.1的寿命和健康寿命。

Sanghuangporus sanghuang extract extended the lifespan and healthspan of DAF-16/SIR-2.1.

作者信息

Dong Zhenghan, Wang Yachao, Hao Cuiting, Cheng Yuan, Guo Xi, He Yanyu, Shi Yueyue, Wang Shuang, Li Yunqi, Shi Wei

机构信息

Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun, Jilin, China.

College of Life Sciences, Jilin University, Changchun, Jilin, China.

出版信息

Front Pharmacol. 2023 Apr 20;14:1136897. doi: 10.3389/fphar.2023.1136897. eCollection 2023.

DOI:10.3389/fphar.2023.1136897
PMID:37153808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10159060/
Abstract

is a fungus species. As a traditional Chinese medicine, it is known for antitumor, antioxidant and anti-inflammatory properties. However, the antiaging effect of has not been deeply studied. In this study, the effects of extract (SSE) supernatants on the changes of nematode indicators were investigated. The results showed that different concentrations of SSE prolonged the lifespans of nematodes and substantially increased these by 26.41%. In addition, accumulations of lipofuscin were also visibly reduced. The treatment using SSE also played a role in increasing stress resistance, decreasing ROS accumulations and obesity, and enhancing the physique. RT-PCR analysis showed that the SSE treatment upregulated the transcription of , , , and , increased the expression of these genes in the insulin/IGF-1 signalling pathway and prolonged the lifespans of nematodes. This study reveals the new role of in promoting longevity and inhibiting stress and provides a theoretical basis for the application of in anti-ageing treatments.

摘要

是一种真菌物种。作为一种传统中药，它以抗肿瘤、抗氧化和抗炎特性而闻名。然而，其抗衰老作用尚未得到深入研究。在本研究中，研究了提取物（SSE）上清液对线虫指标变化的影响。结果表明，不同浓度的SSE延长了线虫的寿命，并使其显著增加了26.41%。此外，脂褐素的积累也明显减少。使用SSE进行的处理在提高抗应激能力、减少活性氧积累和肥胖以及增强体质方面也发挥了作用。RT-PCR分析表明，SSE处理上调了、、、和的转录，增加了这些基因在胰岛素/IGF-1信号通路中的表达，并延长了线虫的寿命。本研究揭示了在促进长寿和抑制应激方面的新作用，并为其在抗衰老治疗中的应用提供了理论依据。

需注意，原文中部分关键基因名称未给出具体内容，翻译时保留了英文原名。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/7796e999ffa3/fphar-14-1136897-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/ba316d52626b/fphar-14-1136897-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/c396138a5e21/fphar-14-1136897-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/4085ea36a0c4/fphar-14-1136897-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/6dface40237c/fphar-14-1136897-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/aa68b7a12acf/fphar-14-1136897-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/df806557a3a0/fphar-14-1136897-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/dac1928c3c6f/fphar-14-1136897-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/ce2ad8e8e3d5/fphar-14-1136897-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/7796e999ffa3/fphar-14-1136897-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/ba316d52626b/fphar-14-1136897-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/c396138a5e21/fphar-14-1136897-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/4085ea36a0c4/fphar-14-1136897-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/6dface40237c/fphar-14-1136897-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/aa68b7a12acf/fphar-14-1136897-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/df806557a3a0/fphar-14-1136897-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/dac1928c3c6f/fphar-14-1136897-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/ce2ad8e8e3d5/fphar-14-1136897-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db35/10159060/7796e999ffa3/fphar-14-1136897-g009.jpg

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