Tutaeva V V, Bobin A N, Ovsiannikova M R, Bulgakova M V, Kuchma Y M, Kryukov E V, Rukavitsyn O A
Department of Hematology, the Main Military Clinical Hospital named after N.N. Burdenko, Moscow, Russia.
Department of Pathology, the Main Military Clinical Hospital named after N.N. Burdenko, Moscow, Russia.
Oxf Med Case Reports. 2020 Sep 22;2020(9):omaa069. doi: 10.1093/omcr/omaa069. eCollection 2020 Sep.
We report a case of a 35-year-old, non-HIV-infected male diagnosed simultaneously with a disseminated form of Kaposi's sarcoma (KS; skin, stomach and colon are involved) and Hodgkin's lymphoma. There is no sign of changes in the immune status, but three herpes viruses were detected in the patient's blood (EBV, HHV6 and HHV8). He received ABVD chemotherapy and achieved complete metabolic remission for Hodgkin's lymphoma. Moreover, the signs of the disseminated KS were resolved. Our observations indicate that a combination of distinct types of viruses may play an important role in triggering the development of angio- and lymphoproliferative disorders in the same person. In addition, treatment with chemotherapy cycles, which included doxorubicin and vinblastine, led to the stable remission of both diseases.
我们报告了一例35岁未感染艾滋病毒的男性病例，该患者同时被诊断为播散型卡波西肉瘤（KS；累及皮肤、胃和结肠）和霍奇金淋巴瘤。免疫状态无变化迹象，但在患者血液中检测到三种疱疹病毒（EBV、HHV6和HHV8）。他接受了ABVD化疗，霍奇金淋巴瘤实现了完全代谢缓解。此外，播散性KS的体征也消失了。我们的观察表明，不同类型病毒的组合可能在触发同一个体血管和淋巴增殖性疾病的发展中起重要作用。此外，包含多柔比星和长春碱的化疗周期治疗使两种疾病均获得稳定缓解。
