Zhao Wancheng, Wang Jingguo, Wang Henan, Lu Shuting, Song Yan, Chen Haixu, Ma Yan, Wang Lei, Sun Tiedong
Key Laboratory of Forest Plant Ecology, Ministry of Education, Engineering Research Center of Forest Bio-Preparation, College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, P. R. China.
Biomater Sci. 2020 Nov 7;8(21):6017-6024. doi: 10.1039/d0bm01015d. Epub 2020 Sep 30.
Nanomaterials with multiple functions such as precision diagnosis, therapeutic efficacy and biosafety are attractive for tumor treatment but remain a technical challenge. In this study, molybdenum (Mo)-based polyoxometalate clusters (Mo-POM) with considerable photothermal conversion efficiency (∼56.6%) and high stability (>30 days) were prepared through a modification of the Folin-Ciocalteu method. These synthetic particles accumulated at the target site, and induced thermal ablation of the tumor following near infrared (NIR) absorption. Furthermore, the Mo-POM effectively scavenged reactive oxygen species (ROS) through charge transfer between Mo(vi) and Mo(v) states, thereby avoiding off-target effects on normal cells and improving the therapeutic efficiency both in vitro and in vivo. Therefore, for the first time, we prepared Mo-POM having two key functions, i.e., photothermal therapy (PTT) for cancer cells and protection of normal cells. These exceptional features may open up the exploration of Mo-POM as new tools for PTT against tumors in clinical applications.
具有精确诊断、治疗效果和生物安全性等多种功能的纳米材料在肿瘤治疗方面具有吸引力，但仍然是一项技术挑战。在本研究中，通过对福林-西奥尔特法进行改进，制备了具有相当高的光热转换效率（约56.6%）和高稳定性（>30天）的钼（Mo）基多金属氧酸盐簇（Mo-POM）。这些合成颗粒在靶位点聚集，并在近红外（NIR）吸收后诱导肿瘤的热消融。此外，Mo-POM通过Mo(Ⅵ)和Mo(Ⅴ)态之间的电荷转移有效地清除活性氧（ROS），从而避免对正常细胞的脱靶效应，并提高体外和体内的治疗效率。因此，我们首次制备了具有两种关键功能的Mo-POM，即对癌细胞进行光热疗法（PTT）和保护正常细胞。这些卓越的特性可能会开启对Mo-POM作为临床应用中对抗肿瘤的PTT新工具的探索。
